2-氨基乙醛 | 6542-88-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-氨基乙醛
• 中文别名: 氨基乙醛
• 英文名称: aminoacetaldehyde
• 英文别名: 2-aminoacetaldehyde；Gly
• CAS: 6542-88-7
• 化学式: C₂H₅NO
• 分子量: 59.0678
• InChiKey: LYIIBVSRGJSHAV-UHFFFAOYSA-N

物化性质

• 沸点：
  60-62 °C(Press: 13 Torr)
• 密度：
  0.9159 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  4
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  2-氨基乙醛 在 sodium hydroxide 、 mercury dichloride 作用下， 生成 吡嗪
  参考文献：
  名称：

  Neuberg; Kansky, Chemische Berichte, 1908, vol. 41, p. 962

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 2-氨基乙醛
  参考文献：
  名称：

  Windaus; Doerries; Jensen, Chemische Berichte, 1921, vol. 54, p. 2748

  摘要：

  DOI：
• 作为试剂：
  描述：

  sodium nitrate 、 zirconyl nitrate 在 2-氨基乙醛 作用下， 以 水 为溶剂， 生成 sodium zirconate
  参考文献：
  名称：

  Investigation on the influence of sodium zirconate nanoparticles on the structural characteristics and electrical properties of polyvinyl alcohol nanocomposite films

  摘要：

  Polyvinyl alcohol (PVA) films doped with varying amounts, viz., 0.5, 1.0 and 2.0 wt.%, of sodium zirconate (Na2ZrO3) were prepared using the solution casting technique in order to investigate the effect of Na2ZrO3 nanoparticle incorporation on the structural, morphological and electrical properties of PVA matrix. The fabricated nanocomposite films have been characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of Na2ZrO3 nanoparticles on the electrical properties of PVA nanocomposites were analyzed by AC conductivity (sigma(ac)), dielectric constant (epsilon'), dielectric loss (epsilon ''), dielectric loss tangent (tan delta) and electric modulus (M ', M '') over a frequency domain from 100 Hz to 1 MHz at room temperature. FT-IR and XRD analysis shows the nature of Na2ZrO3 nanoparticles interaction with the PVA matrix, while SEM images showed uniform dispersion of Na2ZrO3 nanoparticles in PVA matrix. AC conductivity (sigma(ac)) of PVA/Na2ZrO3 nanocomposites increases with increase in filler loading and frequency. The electrical properties such as dielectric constant (epsilon') and dielectric loss (epsilon '') increases with an increase in the amount of nanoparticle, but decreases with frequency. Dielectric loss tangent (tan delta) increases with an increase in nanoparticles concentration, but decreases with frequency. The imaginary part of the electric modulus (M') increases with increase in filler loading except at very low frequency. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jallcom.2012.10.188

文献信息

• [EN] 2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE<br/>[FR] COMPOSÉS DE PYRIDINE 2,3-DISUBSTITUÉS UTILISÉS COMME INHIBITEURS DE TGF-BÊTA ET PROCÉDÉS D'UTILISATION
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2015157093A1

  公开（公告）日：2015-10-15

  The invention described herein comprises compounds of formula (IV) and a method of treating cancer comprising administering to a subject having cancer one of the compounds in conjunction with another therapeutic treatment of cancer. The compounds (IV) inhibit signaling by a member of the TGF-β superfamily such as Nodal or Activin.

  本发明涉及的化合物包括公式（IV）的化合物，以及一种治疗癌症的方法，包括向患有癌症的受试者施用其中一种化合物，结合另一种癌症治疗方法。这些化合物（IV）抑制TGF-β超家族成员如Nodal或Activin的信号传导。
• Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs
  作者：Micah J. Niphakis、Bryant C. Gay、Kwon Ho Hong、Nicholas P. Bleeker、Gunda I. Georg

  DOI：10.1016/j.bmc.2012.07.044

  日期：2012.10

  lack of practical methods for the synthesis of such analogues has limited this effort. Here, we present a concise synthetic approach to N-substituted phenanthropiperidines, which enabled a systematic investigation of structure-activity relationships at an underexplored region of the tylophorine scaffold. This work suggests that ring E of tylophorine is essential for the anti-proliferative activity of the

  tylophorine和许多相关的phenththropiperidine生物碱是非常有效的抗增殖剂。尽管它们具有令人印象深刻的抗癌活性，但这些生物碱的不良溶解性和神经系统副作用阻碍了它们的临床开发。尽管已经提出开发极性菲咯烷吡啶类极性物质将减轻这些不希望的性质，但是缺乏合成此类类似物的实际方法限制了这种努力。在这里，我们为N提供了一种简洁的综合方法-取代的菲咯烷啶，可系统地研究酪氨酸骨架的未充分研究区域的结构-活性关系。这项工作表明，酪氨酸环E对6,7,10,11-四甲氧基-1,2,3,4-四氢二苯并[ f，h ]异喹啉核心骨架的抗增殖活性至关重要。
• Soluble artificial metalloproteases with broad substrate selectivity, high reactivity, and high thermal and chemical stabilities
  作者：Min Gyum Kim、Sang Ho Yoo、Woo Suk Chei、Tae Yeon Lee、Hye Mi Kim、Junghun Suh

  DOI：10.1007/s00775-010-0662-x

  日期：2010.9

  artificial protease and the protein substrate was supported by an experiment using sodium cyanoborohydride. Soluble artificial metalloproteases with broad substrate selectivity, high reactivity, high thermal and chemical stabilities, and small molecular weights were thus synthesized by positioning the aldehyde group in proximity to Cu(II) oxacyclen.

  为了设计可切割各种具有高反应性的蛋白质的肽主链的可溶性人工蛋白酶，合成了包含 1-oxa-4,7,10-三氮杂环十二烷 (oxacyclen) 和醛基的 Cu(II) 复合物的人工活性位点. 鉴于醛基能够与暴露在蛋白质表面的铵基可逆地形成亚胺键，因此采用醛基作为结合位点，并利用 Cu(II) oxacyclen 作为肽水解的催化基团。本研究中合成的人工金属蛋白酶裂解了所有检测的蛋白质底物（白蛋白、γ-球蛋白、肌红蛋白和溶菌酶）。此外，以 kcat/Km 计算，最佳可溶性人工蛋白酶的活性提高了 190 倍。当温度升至80摄氏度时，人工蛋白酶的活性显着增强。人工蛋白酶的活性不受表面活性剂，包括十二烷基硫酸钠的很大影响。在人工蛋白酶和蛋白质底物之间形成的亚胺复合物的中介作用得到了使用氰基硼氢化钠的实验的支持。因此，通过将醛基定位在 Cu(II) oxacyclen 附近，合成了具有广泛底物选择性
• Sulfonamide substituted chroman derivatives useful as beta 3
  申请人：Bayer Corporation

  公开号：US06051586A1

  公开（公告）日：2000-04-18

  This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

  这项发明涉及新型磺胺基取代的色苷衍生物，可用于治疗β-3受体介导的疾病。
• 2-(Imidazol-1-yl)benzophenones
  申请人：The Upjohn Company

  公开号：US03941802A1

  公开（公告）日：1976-03-02

  Compounds of the formulae IV and V: ##SPC1## wherein R.sub.o and R.sub.1 are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.2 is hydrogen, fluoro, chloro, or trifluoromethyl; wherein R.sub.3 is hydrogen or fluoro with the proviso that R.sub.3 cannot be fluoro, if R.sub.2 is chloro or trifluoromethyl; and wherein R.sub.4 is hydrogen, fluoro, chloro, bromo, trifluoromethyl, or nitro, are obtained by a multi-step reaction from the corresponding .alpha.-(phenyl)-o-toluidine of the formula I ##SPC2## wherein R.sub.2, R.sub.3, and R.sub.4 are defined as above, by treating I in sequence with an alkyl ester of orthoformic acid the resulting product with 2-alkyl-2-(aminoalkyl)-1,3-dioxolane or a 2-amino-alkanone dialkyl ketal and finally with titanium tetrachloride to obtain compound IV, and oxidizing compound IV to obtain the corresponding compound V. Compounds IV and V have minor tranquilizing activity which can be utilized to calm mammals or birds. Their more important use, however, is as intermediates in the production of the strongly sedating and tranquilizing imidazolobenzodiazepines.

  化合物IV和V的公式：其中R.sub.o和R.sub.1是氢或1至3个碳原子的烷基；其中R.sub.2是氢，氟，氯或三氟甲基；其中R.sub.3是氢或氟，但R.sub.3不能是氟，如果R.sub.2是氯或三氟甲基；其中R.sub.4是氢，氟，氯，溴，三氟甲基或硝基，可以通过从相应的α-(苯基)-邻甲苯胺的公式I进行多步反应获得##SPC2##其中R.sub.2，R.sub.3和R.sub.4如上定义，通过依次用正甲酸酯处理I，然后用2-烷基-2-(氨基烷基)-1,3-二氧杂环戊烷或2-氨基-烷酮二烷基酮和最后用四氯化钛处理I的结果产品，最终得到化合物IV，然后氧化化合物IV得到相应的化合物V。化合物IV和V具有轻微的镇静作用，可用于使哺乳动物或鸟类镇定。然而，它们更重要的用途是作为生产强烈镇静和镇静作用的咪唑苯二氮卓类药物的中间体。