(oxybis(methylene))diphosphonic acid | 44991-95-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (oxybis(methylene))diphosphonic acid
• 英文别名: 2-oxapropane-1,3-diphosphonic acid；P,P'-(2-oxa-propane-1,3-diyl)-bis-phosphonic acid；bis-phosphonomethyl ether；Dimethylaether-α.α'-diphosphonsaeure；Bis-phosphonomethyl-aether；sym-HMPA ether；Phosphonomethyl ether；phosphonomethoxymethylphosphonic acid
• CAS: 44991-95-9
• 化学式: C₂H₈O₇P₂
• 分子量: 206.029
• InChiKey: SAZNRXNIZCTZBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (oxybis(methylene))diphosphonic acid 、 环己胺 生成 cyclohexanamine;phosphonomethoxymethylphosphonic acid
  参考文献：
  名称：

  MAIER L.; CRUTCHFIELD M. M., PHOSPH. AND SULFUR, 1978, 5, NO 1, 45-51

  摘要：

  DOI：
• 作为产物：
  描述：

  替诺福韦杂质96 在 盐酸 作用下， 生成 (oxybis(methylene))diphosphonic acid
  参考文献：
  名称：

  Abramow; Asanowskaja, Zhurnal Obshchei Khimii, 1942, vol. 12, p. 272

  摘要：

  DOI：

文献信息

• Process for the preparation of N-phosphonomethylglycine and derivatives thereof
  申请人：Coleman P. James

  公开号：US20050054871A1

  公开（公告）日：2005-03-10

  N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.

  N-磷酸甲基胺是通过胺底物与卤甲基膦酸或其盐、羟甲基膦酸或其盐，或羟甲基膦酸的脱水自酯二聚体、三聚体或寡聚体反应而制备的。根据该过程可制备的产品包括N-磷酸甲基氨基羧酸，如草甘膦，N-磷酸甲基氨基烷醇，如羟乙氨基甲基膦酸，以及N-酰氨基甲基膦酸，如N-氨基甲基膦酸。为了推动转化并避免过多形成双(N-磷酸甲基)胺副产物，某些反应中使用大量过量的胺试剂。其他反应使用二次胺底物（如亚胺二乙酸）并可在相当量的卤甲基氨甲膦酸或羟氨甲膦酸与二次胺试剂的摩尔比下进行，而不会显著形成双(磷酸甲基)胺副产物。还公开了通过共沸脱水制备羟甲基膦酸自酯二聚体、三聚体和寡聚体的方法。
• Synthesis and evaluation of novel water-soluble ligands for the complexation of metals during the partitioning of actinides
  作者：Mudassir Iqbal、Jurriaan Huskens、Michal Sypula、Giuseppe Modolo、Willem Verboom

  DOI：10.1039/c1nj20523d

  日期：——

  Different types of water-soluble ligands were synthesized and their capability was evaluated by solvent extraction studies to complex trivalent actinides and suppress their extraction by a strong lipophilic ligand, such as TODGA. The back extraction efficiency of hydrophilic diglycolamide (DGA) derivatives with a varying number of ethylene glycol groups, or containing sodium acetate moieties on the amidic nitrogen shows a decrease in back-extraction efficiency with increasing number of ethylene glycol units on the amidic nitrogen at various pH values of the aqueous phase. Among the PS donating ligands only the ligand with a malonamide backbone exhibits a high reverse extraction efficiency, although, with no selectivity for americium. Within the water-soluble tripodal ligands, i.e. the amide derivatives of nitrilotriacid with N,N-dimethyl and N,N-bis(hydroxyethyl) moieties, the first one shows a pronounced selectivity for Am(III) over Eu(III), with a maximum separation factor of 11.1, while the latter one more efficiently complexes the radionuclides in the aqueous phase with a maximum separation factor of 5. Isothermal microcalorimetry experiments of the complexation of Eu(III) by a selected series of ligands confirm the observed trend in the back extraction properties.

  合成了不同类型的水溶性配体，并通过溶剂萃取研究评估了它们络合三价锕系元素的能力，并通过强亲脂配体（例如 TODGA）抑制其萃取。具有不同数量乙二醇基团或酰胺氮上含有乙酸钠部分的亲水性二甘醇酰胺 (DGA) 衍生物的反萃取效率表明，随着不同温度下酰胺氮上乙二醇单元数量的增加，反萃取效率会降低。水相的pH值。在 PS 供体配体中，只有具有丙二酰胺主链的配体表现出高反萃取效率，但对镅没有选择性。在水溶性三足配体（即带有 N,N-二甲基和 N,N-双（羟乙基）部分的次氮基三酸的酰胺衍生物）中，第一个配体对 Am(III) 表现出比 Eu(III) 显着的选择性，其中最大分离因子为 11.1，而后者更有效地络合水相中的放射性核素，最大分离因子为 5。通过一系列选定的配体络合 Eu(III) 的等温微量热实验证实了观察到的趋势反萃取特性。
• Condensation of diethylphosphorous acid with formaldehyde and triethyl phosphite
  作者：B. E. Ivanov、L. A. Kudryavtseva、T. A. Zyablikova、T. G. Bykova、�. I. Gol'dfarb

  DOI：10.1007/bf00857398

  日期：1971.7
• [EN] METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN ALPHA-OXY PHOSPHORUS GROUP BY USING P-X COMPONENTS<br/>[FR] PROCÉDÉ POUR LA FABRICATION DE COMPOSÉS CONTENANT UN GROUPE ALPHA-OXY-PHOSPHORÉ À L'AIDE DE COMPOSANTS P-X
  申请人：STRAITMARK HOLDING AG

  公开号：WO2013017564A3

  公开（公告）日：2013-05-02
• Abramow; Asanowskaja, Zhurnal Obshchei Khimii, 1942, vol. 12, p. 272
  作者：Abramow、Asanowskaja

  DOI：——

  日期：——