diethyl α-acetoxyethanephosphonate | 4124-94-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: diethyl α-acetoxyethanephosphonate
• 英文别名: diethyl (1-acetoxyethyl)phosphonate；(1-acetoxy-ethyl)-phosphonic acid diethyl ester；(1-Acetoxy-aethyl)-phosphonsaeure-diaethylester；(diethoxyphosphinyl)-ethyl acetate；(diethoxyphosphoryl)ethyl acetate；(1-Acetoxy-ethyl)-phosphonsaeure-diethylester；1-(Diethoxyphosphoryl)ethyl acetate；1-diethoxyphosphorylethyl acetate
• CAS: 4124-94-1
• 化学式: C₈H₁₇O₅P
• 分子量: 224.194
• InChiKey: DPXYOLOTFDZJPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2931900090

反应信息

• 作为产物：
  描述：

  diethyl 1-hydroxyethylphosphonate 在 吡啶 作用下， 生成 diethyl α-acetoxyethanephosphonate
  参考文献：
  名称：

  Lebedev,E.P. et al., Journal of general chemistry of the USSR, 1979, vol. 49, p. 1517 - 1522

  摘要：

  DOI：

文献信息

• Novel azole or triazole derivatives, method for preparing same and use thereof as fungicides
  申请人：Babin Didier

  公开号：US20050043540A1

  公开（公告）日：2005-02-24

  The invention concerns novel azole or triazole derivatives of formula (I), wherein X, Ar 1 , Ar 2 , Ar 3 , A, B, and R 1 are as defined herein, their preparation method and their use as fungicides.

  这项发明涉及式(I)的新型唑类或三唑类衍生物，其中X、Ar1、Ar2、Ar3、A、B和R1如本文所定义，它们的制备方法以及它们作为杀菌剂的用途。
• HETEROCYCLIC COMPOUND AND USE THEREOF
  申请人：Kuroita Takanobu

  公开号：US20100137281A1

  公开（公告）日：2010-06-03

  The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like, which is useful for the prophylaxis or treatment s of circulatory diseases such as hypertension, cardiac diseases, arteriosclerosis, renal diseases, cerebral apoplexy and the like and/or metabolic diseases such as hyperlipidemia, obesity, diabetes and the like, central nervous disorders such as cerebral infarction and the like, mental diseases such as dementia, depression and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明旨在提供一种具有优异的药理作用、物理化学性质等的化合物，该化合物对预防或治疗循环系统疾病，如高血压、心脏疾病、动脉硬化、肾脏疾病、脑卒中等，和/或代谢性疾病，如高脂血症、肥胖、糖尿病等，中枢神经系统疾病，如脑梗死等，精神疾病，如痴呆、抑郁症等，等方面具有用途。该化合物由式（I）所表示，其中每个符号如规范中所定义，或其盐。
• Heterocyclic compound and use thereof
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2253630A1

  公开（公告）日：2010-11-24

  The present invention aims to provide a compound having superior pharmacological action, physicochemical properties and the like, which is useful for the prophylaxis or treatment of circulatory diseases such as hypertension, cardiac diseases, arteriosclerosis, renal diseases, cerebral apoplexy and the like and/or metabolic diseases such as hyperlipidemia, obesity, diabetes and the like, central nervous disorders such as cerebral infarction and the like, mental diseases such as dementia, depression and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

  本发明旨在提供一种具有优异药理作用、理化性质等的化合物，该化合物可用于预防或治疗循环系统疾病，如高血压、心脏病、动脉硬化、肾病、脑中风等，和/或代谢性疾病，如高脂血症、肥胖症、糖尿病等，中枢神经疾病，如脑梗塞等，精神疾病，如痴呆症、抑郁症等。 由式（I）代表的化合物： 其中各符号如说明书中所定义，或其盐。
• Organophosphorus Chemistry. Addition Reactions of Diethyl Phosphonate and the Oxidation of Triethyl Phosphite¹
  作者：M. S. KHARASCH、ROBERT A. MOSHER、IRVING S. BENGELSDORF

  DOI：10.1021/jo01076a035

  日期：1960.6
• An Efficient Route to Chiral α- and β-Hydroxyalkanephosphonates
  作者：Oscar Pàmies、Jan-E. Bäckvall

  DOI：10.1021/jo026888m

  日期：2003.6.1

  Enzymatic kinetic resolution of alpha- and beta-hydroxyphosphonates in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic hydroxyphosphonates were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and yield up to 87%).