1-phenyl-indan-2-carboxylic acid | 101110-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-phenyl-indan-2-carboxylic acid
• 英文别名: acide phenyl-1 indanecarboxylique-2 cis
• CAS: 101110-07-0；121926-17-8；121926-22-5
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: GMTZBRZBEJZEQR-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.08
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  bromophenylmethyl-1 bromomethyl-2 benzene 在 氢氧化钾 、 sodium hydride 作用下， 以 乙二醇二甲醚 、 乙醇 为溶剂， 反应 8.0h， 生成 1-phenyl-indan-2-carboxylic acid
  参考文献：
  名称：

  Canonne, P.; Plamondon, J., Canadian Journal of Chemistry, 1989, vol. 67, p. 555 - 564

  摘要：

  DOI：

文献信息

• Indane modulators of glucocorticoid receptor, AP-1, and/or NF/kB activity and use thereof
  申请人：Duan Jingwu

  公开号：US20070185056A1

  公开（公告）日：2007-08-09

  Novel non-steroidal compounds are provided that are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases having the structure of formula (I): or enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, where X is -A 1 QA 2 -; Q is a bond, —C(═O)—, —OC(O)—, —C(═O)NR 5 —, —SO p —, —SO p NR 5 —, —C(O)O—, —NR 5 C(O)—, —OC(O)NR 5 —, —NR 5 C(O)O—, —S(O) p NR 5 C(O)—, —C(O)NR 5 S(O) p — —NR 5 S(O) p —, or —NR 5 C(═O)NR 6 —. Y is selected from hydrogen, C 1-4 alkyl, OR 16 , substituted C 1-6 alkyl, cycloalkyl, aryl, heterocyclo and heteroaryl. A 1 and A 2 are independently selected from a bond, C 1-3 alkylene, or C 1-3 alkenylene, and R 1 -R 11 are defined herein. Also provided are pharmaceutical compositions, combinations, and methods of treating obesity, diabetes and inflammatory- or immune-associated diseases comprising said compounds.

  提供了一种新型的非甾体化合物，可用于治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病，包括肥胖、糖尿病、炎症性和免疫性疾病，其具有以下结构的化学式（I）： 或其对映体、非对映体、药用可接受的盐或水合物，其中X为-A 1 QA 2 -；Q为键，—C(═O)—，—OC(O)—，—C(═O)NR 5 —，—SO p —，—SO p NR 5 —，—C(O)O—，—NR 5 C(O)—，—OC(O)NR 5 —，—NR 5 C(O)O—，—S(O) p NR 5 C(O)—，—C(O)NR 5 S(O) p —，—NR 5 S(O) p —，或—NR 5 C(═O)NR 6 —。Y从氢、C 1-4 烷基、OR 16 、取代的C 1-6 烷基、环烷基、芳基、杂环烷基和杂芳基中选择。A 1 和A 2 独立选择自键、C 1-3 烷基或C 1-3 烯基，R 1 -R 11 在此定义。还提供了包含所述化合物的药物组合物、组合物和治疗肥胖、糖尿病和炎症性或免疫相关疾病的方法。
• Lewis acid-mediated β-selective hydrocarboxylation of α,α-diaryl- and α-arylalkenes with R3SiH and CO2
  作者：Shinya Tanaka、Yuuki Tanaka、Masafumi Chiba、Tetsutaro Hattori

  DOI：10.1016/j.tetlet.2015.04.090

  日期：2015.6

  alpha,alpha-Diarylalkenes are successfully hydrocarboxylated with Et3SiH and CO2 with the aid of Et3SiB(C6F5)(4) or EtAlCl2/Ph3SiCl to give carboxylic acids with a carboxy group at the beta-position to the aryl groups. The EtAlCl2/Ph3SiCl-mediated reaction is also applicable to various alpha-arylalkenes. H-1 NMR analysis of a mixture of EtAlCl2, Ph3SiCl, and Et3SiH strongly suggests the formation of a mu-H complex, [Ph3Si-H-SiEt3](+) AlEtCl3-, which is an equivalent of R3Si+ ions, while Et3SiB(C6F5)(4) is an ion pair with a Et3Si+ ion. Therefore, in these reaction systems, a siloxycarbonylium, R3Si-O-C O+, is considered to be a common electrophile, the addition of which to the substrate, followed by trapping of the resulting cationic species with Et3SiH seems to afford the desired acid after aqueous workup. (C) 2015 Elsevier Ltd. All rights reserved.