6-fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one | 691378-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one
• 英文别名: 6-Fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one；6-fluoro-3-[2-(3-fluorophenyl)ethyl]-2-(2-hydroxyphenyl)quinazolin-4-one
• CAS: 691378-50-4
• 化学式: C₂₂H₁₆F₂N₂O₂
• 分子量: 378.378
• InChiKey: RIDQHUPWZIRXMP-UHFFFAOYSA-N

物化性质

• 沸点：
  555.0±60.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  sodium hydride 、 6-fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one 以 乙腈 为溶剂， 以81%的产率得到6-fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one sodium salt
  参考文献：
  名称：

  [EN] QUINAZOLINONE COMPOUNDS AS CALCILYTICS
  [FR] COMPOSES DE QUINAZOLINONE UTILISES COMME CALCILYTIQUES

  摘要：

  公开号：

  WO2004041755A3
• 作为产物：
  描述：

  2-氨基-5-氟苯甲酸 在 吡啶 作用下， 生成 6-fluoro-3-[2-(3-fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one
  参考文献：
  名称：

  3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

  摘要：

  Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic bit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.01.078

文献信息

• Quinazolinone compounds as calcilytics
  申请人：Shcherbakova Irina

  公开号：US20060052345A1

  公开（公告）日：2006-03-09

  Various calcilytic compounds and pharmaceutical compositions containing these compounds are disclosed. Calcilytic compounds are compounds capable of inhibiting calcium receptor activity. Techniques which can be used to obtain calcilytic compounds and uses of calcilyitc compounds as calcium receptor antagonists are also disclosed.

  本文揭示了各种钙离子受体抑制剂化合物及含有这些化合物的制药组合物。钙离子受体抑制剂化合物是一种能够抑制钙离子受体活性的化合物。本文还揭示了可用于获得钙离子受体抑制剂化合物的技术以及将钙离子受体抑制剂化合物用作钙离子受体拮抗剂的用途。
• ACTIVE ENERGY RAY-CROSSLINKABLE THERMOPLASTIC POLYMER AND COMPOSITION CONTAINING SAME
  申请人：Kuraray Co., Ltd.

  公开号：EP3943299A1

  公开（公告）日：2022-01-26

  The present invention provides a polymer which has a polymerizable functional group but still can be thermoformed without being crosslinked and which undergoes crosslinking upon irradiation with an active energy ray after being formed, and a composition including the polymer. An active energy ray crosslinkable thermoplastic polymer includes specific monomer units (1). The ratio of the number of moles of the monomer units represented by the general formula (1) to the number of moles of all monomer units constituting the polymer is not less than 1 mol%. The number average molecular weight (Mn) of the active energy ray crosslinkable thermoplastic polymer is 20,000 to 500,000.

  本发明提供了一种具有可聚合官能团但仍可热成型而无需交联的聚合物，该聚合物在成型后经活性能量射线照射后会发生交联，本发明还提供了一种包括该聚合物的组合物。活性能量射线可交联热塑性聚合物包括特定的单体单元 (1)。通式（1）所代表的单体单元摩尔数与构成聚合物的所有单体单元摩尔数之比不小于 1 摩尔%。活性能量射线可交联热塑性聚合物的平均分子量（Mn）为 20,000 至 500,000。
• Anionic polymerization process, and process for producing a polymer by the anionic polymerization process
  申请人：KURARAY CO., LTD.

  公开号：EP1078942B1

  公开（公告）日：2006-06-07
• EP1558260A4
  申请人：——

  公开号：EP1558260A4

  公开（公告）日：2006-10-25
• QUINAZOLINONE COMPOUNDS AS CALCILYTICS
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1558260A2

  公开（公告）日：2005-08-03