(叔丁基酰亚氨)三氧化锇 | 50381-48-1

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: (叔丁基酰亚氨)三氧化锇
• 英文名称: Trioxoosmium(VIII)-tert.-butylimide
• 英文别名: trioxo(tert-butylimido)osmium；trioxo(N-tert-butylimido)osmium(VIII)；Trioxo(tert.-butylimido)osmium(VIII)；tert.-Butylimido-Osmiumtrioxid；(tert-butylaminato(2-)-N)-trioxo-osmium；trioxo (t-butylimido)osmium(VIII)；Tert-butylimino(trioxo)osmium
• CAS: 50381-48-1
• 化学式: C₄H₉NO₃Os
• 分子量: 309.32
• InChiKey: JRHXKAIOLBLETF-UHFFFAOYSA-N

物化性质

• 熔点：
  110 °C
• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2925290090
• 储存条件：
  存放于0至6℃阴凉干燥处

SDS

Name:	(tert-Butylimido)osmium trioxide Material Safety Data Sheet
Synonym:
CAS:	50381-48-1

Section 1 - Chemical Product MSDS Name:(tert-Butylimido)osmium trioxide Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
50381-48-1	(tert-Butylimido)osmium trioxide		unlisted

Hazard Symbols: T
Risk Phrases: 23/24/25

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Toxic in contact with skin.
Ingestion:
May cause irritation of the digestive tract. Toxic if swallowed.
Inhalation:
May cause respiratory tract irritation. Toxic if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid immediately. Wash mouth out with water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Do not store in direct sunlight. Keep refrigerated. (Store below 4C/39F.) Store in a tightly closed container. Store in a dry area.
Store under nitrogen.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 50381-48-1: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow to yellow-green
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 110 deg C(dec.)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C4H9NO3Os
Molecular Weight: 309.32

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Light sensitive.
Conditions to Avoid:
Incompatible materials, light.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 50381-48-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(tert-Butylimido)osmium trioxide - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: II
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: II
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: II

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
Safety Phrases:
S 22 Do not breathe dust.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 50381-48-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 50381-48-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 50381-48-1 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (叔丁基酰亚氨)三氧化锇 在 KOH 作用下， 生成 potassium osmate
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Os: SVol.1, 4.2.10, page 239 - 241

  摘要：

  DOI：
• 作为产物：
  描述：

  四氧化锇 、 叔丁胺 以 正戊烷 为溶剂， 生成 (叔丁基酰亚氨)三氧化锇
  参考文献：
  名称：

  Stereospecific vicinal oxyamination of olefins by alkylimidoosmium compounds

  摘要：

  DOI：

  10.1021/jo00407a016
• 作为试剂：
  描述：

  8-甲氧基-2,6-二甲基辛-2-烯 在 吡啶 、 lithium aluminium tetrahydride 、 (叔丁基酰亚氨)三氧化锇 作用下， 生成 3,7-dimethyl-1-methoxy-6,7-octanediol 、 3-(Tert-butylamino)-8-methoxy-2,6-dimethyl-2-octanol
  参考文献：
  名称：

  Improved procedure for the oxyamination of olefins with trioxo(tert-butylimido)osmium(VIII)

  摘要：

  DOI：

  10.1021/jo01299a045

文献信息

• Zur Reaktion von olefinischen Monoterpenen mit Trioxoosmium(VIII)-tert.-butylimid
  作者：G. Rücker、M. Neugebauer、B. Daldrup

  DOI：10.1002/ardp.19883211115

  日期：——

  Reaction of olefinic monoterpenes with trioxoosmium(VIII)‐tert.‐butylimide

  烯烃单萜与三氧锇(VIII)-叔丁基酰亚胺的反应
• Diamination of Olefins: Synthesis, Structures and Reactivity of Osmaimidazolidines
  作者：Kilian Muñiz、Atsushi Iesato、Martin Nieger

  DOI：10.1002/chem.200305011

  日期：2003.11.21

  obtained from olefin difunctionalisation were characterised by X-ray analysis for the first time. Kinetic studies on the reaction profile have also been carried out. An asymmetric version of this reaction is based on chiral non-racemic auxiliaries and leads to diastereomerically enriched osmaimidazolidines with up to 90 % de. This sequence represents the first asymmetric diamination of olefins. Attempts

  某些带有吸电子取代基的烯烃的氨化反应与well的明确定义的双亚simido和三亚simido配合物一起进行。获得的产物为奥沙咪唑烷，其在烯烃官能化方面具有前所未有的稳定性。来自相关的二羟基化或氨基羟基化的complex络合物的稳定性显着降低，从而促进了催化反应。已经研究了反应曲线的这种差异，并且首次通过X射线分析对由烯烃双官能化获得的手性杂环进行了表征。还已经进行了关于反应曲线的动力学研究。该反应的不对称形式基于手性非外消旋助剂，可导致非对映异构富集的奥斯麦咪唑烷含量高达90％de。该序列代表烯烃的第一次不对称金属化。讨论了将手性配体用于直接不对称氨化的尝试，以及奥沙咪唑烷性质对催化反应的影响。
• Homoleptic t-butylimido compounds of osmium(VIII) and chromium(VI)
  作者：Andreas A. Danopoulos、Geoffrey Wilkinson

  DOI：10.1016/s0277-5387(00)84305-3

  日期：1990.1
• New reaction. Stereospecific vicinal oxyamination of olefins by alkyl imido osmium compounds
  作者：K. Barry Sharpless、Donald W. Patrick、Larry K. Truesdale、Scott A. Biller

  DOI：10.1021/ja00841a071

  日期：1975.4
• McGilligan, Brian S.; Arnold, John; Wilkinson, Geoffrey, Journal of the Chemical Society, Dalton Transactions
  作者：McGilligan, Brian S.、Arnold, John、Wilkinson, Geoffrey、Hussain-Bates, Bilquis、Hursthouse, Michael B.

  DOI：——

  日期：——