4-((hydroxyamino)methyl)benzene-1,3-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-((hydroxyamino)methyl)benzene-1,3-diol
• 英文别名: 2,4-dihydroxybenzylhydroxylamine；4-[(hydroxyamino)methyl]benzene-1,3-diol
• 化学式: C₇H₉NO₃
• 分子量: 155.153
• InChiKey: MVJGVEVPAGILEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-((hydroxyamino)methyl)benzene-1,3-diol 在 亚硝酸丁酯 、 氨 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 反应 0.67h， 生成
  参考文献：
  名称：

  Synthesis and tyrosinase inhibitory activity of novel N-hydroxybenzyl-N-nitrosohydroxylamines

  摘要：

  Several novel N-substituted N-nitrosohydroxylamines were synthesized. They all inhibited mushroom tyrosinase, but the type of inhibition was different depending on the substituent. Some N-(mono- or dihydroxybenzyl)-N-nitrosohydroxylamines exhibited uncompetitive inhibition with respect to (L)-dopa. Among them, compound 6 was also a competitive inhibitor with respect to oxygen. This observation suggests that another interaction by the meta- or para-hydroxyl group might stabilize the binding of the inhibitor to the enzyme through the oxygen binding site. (C) 2003 Elsevier Science (USA). All rights reserved.

  DOI：

  10.1016/s0045-2068(03)00026-9
• 作为产物：
  描述：

  2,4-二羟基苯甲醛肟 在 盐酸 、 methyl orange 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 4-((hydroxyamino)methyl)benzene-1,3-diol
  参考文献：
  名称：

  Synthesis and tyrosinase inhibitory activity of novel N-hydroxybenzyl-N-nitrosohydroxylamines

  摘要：

  Several novel N-substituted N-nitrosohydroxylamines were synthesized. They all inhibited mushroom tyrosinase, but the type of inhibition was different depending on the substituent. Some N-(mono- or dihydroxybenzyl)-N-nitrosohydroxylamines exhibited uncompetitive inhibition with respect to (L)-dopa. Among them, compound 6 was also a competitive inhibitor with respect to oxygen. This observation suggests that another interaction by the meta- or para-hydroxyl group might stabilize the binding of the inhibitor to the enzyme through the oxygen binding site. (C) 2003 Elsevier Science (USA). All rights reserved.

  DOI：

  10.1016/s0045-2068(03)00026-9

文献信息

• [EN] NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE<br/>[FR] COMPOSÉS NITRONES ET LEUR UTILISATION DANS LES SOINS PERSONNELS
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2015134688A1

  公开（公告）日：2015-09-11

  Provided are compounds and compositions thereof that are useful as antioxidants in personal care formulations. The compounds are of the Formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are independently H, C1-C10 alkyl, -OH, C1-C6 alkoxy, -COOH, -COO-M+, or -O-V+, where M+ is a sodium, potassium, or ammonium ion, provided that at least one of R6, R7, R8, R9, or R10 is -OH.

  提供了化合物及其组合物，可作为个人护理配方中的抗氧化剂。这些化合物属于Formula I：其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10分别独立地是H、C1-C10烷基、-OH、C1-C6烷氧基、-COOH、-COO-M+或-O-V+，其中M+是钠、钾或铵离子，但至少其中一个为-OH。
• Primary N-hydroxylamines
  申请人：——

  公开号：US20040110729A1

  公开（公告）日：2004-06-10

  The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.

  本发明提供了由伯胺基 N-羟胺组成的药物组合物以及相关的治疗、预防、诊断和筛查方法。这些药物组合物一般包括一种药物组合物，其中含有可口服的有效单位固体剂量的伯羟胺或其药学上可接受的盐，并且基本上不含与羟胺相对应的腈酮。
• NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE
  申请人：Dow Global Technologies LLC

  公开号：EP3114110A1

  公开（公告）日：2017-01-11
• JP2004315496A
  申请人：——

  公开号：JP2004315496A

  公开（公告）日：2004-11-11
• US6455589B1
  申请人：——

  公开号：US6455589B1

  公开（公告）日：2002-09-24