6-methoxybenzofuran-2-carbonyl chloride | 50963-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 6-methoxybenzofuran-2-carbonyl chloride
• 英文别名: 6-Methoxy-1-benzofuran-2-carbonyl chloride
• CAS: 50963-49-0
• 化学式: C₁₀H₇ClO₃
• 分子量: 210.617
• InChiKey: LFLIRHTVIYEVMA-UHFFFAOYSA-N

物化性质

• 沸点：
  304.5±22.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methoxybenzofuran-2-carbonyl chloride 在 三甲基溴硅烷 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 5.0h， 生成 6-methoxy-benzofuran-2-carboxylic acid phosphonoethyl ester
  参考文献：
  名称：

  Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties

  摘要：

  The bone morphogenetic protein (BMP) pathway is a promising new target for the design of therapeutic agents for the treatment of low bone mass. This study optimized the structure of the anti-osteoporosis compound 38 by balancing its lipophilicity and improving its stability. Twenty derivatives which were not reported in the literature were designed and synthesized. The ovariectomized rat model of osteoporosis was selected to evaluate the therapeutic effects. Compound 125 showed better therapeutic efficacy than that of 38. We verified the anti-osteoporosis activity and BMP-2 protein upregulation after treatment with 125 in a zebrafish osteoporosis model. We found that 125 improved the ADME properties, therapeutic efficacy, and pharmacokinetics of the drug. Overall, we evaluated the anti-osteoporosis effects of the compounds of this type, preliminarily determined the target patient population, verified the mechanism of action, clarified the level of toxicity, and provided preliminary ADME data. We believe that these compounds can both correct bone loss that is already occurring in patients and have broad clinical applicability. (C) 2020 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2020.112465
• 作为产物：
  描述：

  6-甲氧基苯并呋喃-2-羧酸 在 五氯化磷 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 6-methoxybenzofuran-2-carbonyl chloride
  参考文献：
  名称：

  Synthesis of 2,3-Dimethoxy-7-methyl-7,12-dihydro-6H-[1]-benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione

  摘要：

  用 PPA 处理 5,6-二甲氧基-2-（甲基苯基氨基甲酰基）-苯并呋喃-3-羧酸可生成 2,3-二甲氧基-7-甲基-7,12-二氢-6H-[1]-苯并呋喃-[2,3-c]-[1]-苯并氮杂卓-6,12-二酮。类似的 2-[(5,6-二甲氧基苯并呋喃-2-羰基)甲基氨基]苯甲酸不易发生环化反应，而 2-[(6-甲氧基苯并呋喃-2-羰基)氨基]苯甲酸则发生环化反应，生成相应的 3,1-苯并恶嗪-4-酮。

  DOI：

  10.3390/70300353

文献信息

• Arylmethylenyl derivatives of imidazolidinones useful as
  申请人：Warner-Lambert Company

  公开号：US05464856A1

  公开（公告）日：1995-11-07

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.

  本发明涉及一些新颖的化合物，以及这些新颖化合物的药物组成和用于治疗过敏和炎症的方法，其中这些化合物的公式为##STR1##。这些化合物已知，并具有治疗过敏和炎症的活性。
• Known and selected novel arylmethylenyl derivatives of thiazolidinones,
  申请人：Warner-Lambert Company

  公开号：US05208250A1

  公开（公告）日：1993-05-04

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.

  本发明涉及选定的新化合物，以及药物组合物和使用方法，其中所述选定的新化合物的化学式为##STR1##具有治疗过敏和炎症活性。
• Arylmethylenyl derivatives of oxazolidinone
  申请人：Warner-Lambert Company

  公开号：US05306822A1

  公开（公告）日：1994-04-26

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.

  本发明涉及选定的新化合物，以及用于已知和选定的新化合物的制药组合物和使用方法，其具有有用于治疗过敏和炎症的活性，其分子式为##STR1##。
• Arylmethylenyl derivatives of thiazolidnones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflamatory agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0343643A2

  公开（公告）日：1989-11-29

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula having activity useful for treating allergies and inflammation.

  本发明涉及所选的新型化合物，以及已知和所选的新型化合物的药物组合物和使用方法，这两种化合物的化学式均为 具有治疗过敏症和炎症的活性。
• Deshpande, A. R.; Joshi, U. K.; Paradkar, M. V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 524 - 526
  作者：Deshpande, A. R.、Joshi, U. K.、Paradkar, M. V.

  DOI：——

  日期：——