维他命D3硫酸酯钠盐 | 78392-27-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 维他命D3硫酸酯钠盐
• 英文名称: Vitamin D3 sulfate sodium salt
• 英文别名: sodium cholecalciferol sulfate；Vitamin D3 Sulfate Sodium Salt；sodium;[(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexyl] sulfate
• CAS: 78392-27-5
• 化学式: C₂₇H₄₃O₄S*Na
• 分子量: 486.692
• InChiKey: HZXPJUMUSRXXKW-DRFPHCMDSA-M

物化性质

• 熔点：
  113-114°C
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  4.11
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险等级：
  6.1(a)
• 安全说明：
  S36
• 危险类别码：
  R22
• 危险品运输编号：
  UN 3249

反应信息

• 作为产物：
  描述：

  维生素 D3 在 吡啶 、 三氧化硫吡啶 、 sodium chloride 作用下， 反应 1.33h， 生成 维他命D3硫酸酯钠盐
  参考文献：
  名称：

  US11819507

  摘要：

  公开号：

文献信息

• Cholecalciferol sulfate identification in human milk by HPLC
  作者：N Le Boulch、L. Cancela、L. Miravet

  DOI：10.1016/0039-128x(82)90063-0

  日期：1982.4

  Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitamin D3 sulfate sodium salt was used as a reference. Milk whey was obtained after protein precipitation by adding ethanol. Vitamin D3 sulfoconjugate was identified in supernatant (lyophylized) after purification by Sephadex LH 20 and HPLC. Milk whey purified fraction obtained exhibited the same ultra-violet absorption (UV) as synthetic vitamin D3 sulfate; after solvolysis, cholecalciferol was liberated from natural and synthetic sulfoconjugate. The results confirmed that vitamin D3 sulfate was present in human milk.
• CHOLECALCIFEROL SULFATE SALTS AND THEIR USE FOR THE TREATMENT OF VITAMIN D DEFICIENCY
  申请人：CFSO GMBH

  公开号：US20180200269A1

  公开（公告）日：2018-07-19

  Pharmaceutically acceptable cholecalciferol sulfate salts are used for combating vitamin D 3 deficiency. New cholecalciferol sulfate salts as well as pharmaceutical compositions of the pharmaceutically acceptable cholecalciferol sulfate salts are described as well.
• US5885974A
  申请人：——

  公开号：US5885974A

  公开（公告）日：1999-03-23
• US6303588B1
  申请人：——

  公开号：US6303588B1

  公开（公告）日：2001-10-16
• [EN] CORRECTING BIOLOGICAL INFORMATION TRANSFER USING THREE BIOLOGICAL INFORMATION BLOCKS<br/>[FR] CORRECTION DU TRANSFERT D'INFORMATIONS BIOLOGIQUES A L'AIDE DE TROIS BLOCS D'INFORMATION BIOLOGIQUE
  申请人：DNS SCIENTIFIC, INC.

  公开号：WO1996017621A1

  公开（公告）日：1996-06-13

  (EN) Methods are disclosed for correcting biological information transfer in a patient in need of such therapy which comprise administration to a patient of a composition comprising a therapeutically effective amount of a biocomplex comprising at least one bioactive agent from each of the three informational blocks of biological information transfer, each agent being present in an amount sufficient to correct the biological information transfer of the patient under treatment and resulting in the resumption of normal cell metabolism, said amount being less than the buffering amount of said agent; together with a carrier therefor.(FR) Cette invention concerne des procédés visant à corriger le transfert d'informations biologiques chez un patient dont l'état nécessite un tel traitement. Ces procédés consistent à administrer au patient une composition contenant un complexe biologique en quantité thérapeutiquement efficace. Ce complexe biologique comprend au moins un agent bioactif issu de chacun des trois blocs d'information employés dans le transfert d'information biologique. Chaque agent doit être présent en quantité suffisante de manière à corriger le transfert d'informations biologiques du patient sous traitement, ce qui permettra de rétablir un métabolisme cellulaire normal. Cette quantité doit être inférieure à la quantité tampon dudit agent. Cette invention concerne également un dispositif pour l'administration de la composition.