Adefovir & PMPA

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Adefovir & PMPA
• 英文别名: 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid;[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
• 化学式: C17H26N10O8P2
• 分子量: 560.4
• InChiKey: AQZIPWNQCGTDIV-FYZOBXCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.49
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  273
• 氢给体数：
  6
• 氢受体数：
  16

文献信息

• [EN] (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF<br/>[FR] TRANS-ISOMERES (+) DE DERIVES DE NUCLEOSIDE ( 1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL)METHYLE, PROCESSUS DE PREPARATION DE STEREO-ISOMERES DE CEUX-CI ET UTILISATION D'AGENTS ANTIVIRAUX A BASE CEUX-CI
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2004029064A1

  公开（公告）日：2004-04-08

  The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2- alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.

  本发明涉及公式（1）的（+）-反式异构体（1-磷酸甲氧基-2-烷基环丙基）甲基核苷衍生物，该衍生物可用作抗病毒剂（特别是对乙型肝炎病毒），其药用盐、水合物或溶剂化合物，以及用于制备公式（1）化合物的立体异构体的方法，以及一种用于治疗病毒性疾病（特别是对乙型肝炎病毒）的组合物，包括公式（1）化合物的（+）-反式异构体，其药用盐、水合物或溶剂化合物作为活性物质。
• (+)-Ttrans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
  申请人：Choi Jong-Ryoo

  公开号：US20060111324A1

  公开（公告）日：2006-05-25

  The present invention relates to (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl)methyl nucleoside derivatives of the formula (1) which are useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable saltss, hydrates, or solvates thereof, and processes for the preparation of stereoisomers of the compounds of the formula (1), and a composition for the treatment of viral diseases (particularly, against hepatitis B virus) comprising (+)-trans-isomer of the compound of the formula (1), pharmaceutically acceptable salt, hydrate, or solvate thereof as an active substance.

  本发明涉及公式（1）的（1-磷酸甲氧基-2-烷基环丙基）甲基核苷衍生物的（+）-顺式异构体，其可用作抗病毒剂（特别是对乙型肝炎病毒），其药学上可接受的盐，水合物或溶剂化物，以及制备公式（1）化合物的立体异构体的过程，以及一种用于治疗病毒性疾病（特别是对乙型肝炎病毒）的组合物，包括公式（1）化合物的（+）-顺式异构体，其药学上可接受的盐，水合物或溶剂化物作为活性物质。
• (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF
  申请人：LG Life Sciences Ltd.

  公开号：EP1546164A1

  公开（公告）日：2005-06-29
• EP1546164A4
  申请人：——

  公开号：EP1546164A4

  公开（公告）日：2006-06-07
• PRODRUGS ACTIVATED BY RNA-DEPENDENT DNA-POLYMERASES
  申请人：Protera S.R.L.

  公开号：EP1778254A2

  公开（公告）日：2007-05-02