| 107484-93-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机碱土金属化合物
• CAS: 107484-93-5
• 化学式: C₁₀H₁₁BrMgO₂
• 分子量: 267.405
• InChiKey: GZGCFCCFHWRJRD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.55
• 重原子数：
  14.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  在 copper(l) iodide 、 三丁基膦 作用下， 以 四氢呋喃 为溶剂， 生成 (S)-benzyl 1-(3-(2-hydroxypropan-2-yl)phenyl)propan-2-ylcarbamate
  参考文献：
  名称：

  Comparative approaches toward diamines containing spatially separated homobenzylic and benzylic nitrogen stereocenters

  摘要：

  Several synthetic strategies to diamines 1-3 are described. The optimum approach via opening of aziridine afforded 1 3 in 29-60% yield over 3-5 steps. A study on formation of the benzylic stereocenter using Toste's rhenium-catalyzed asymmetric reduction of phosphinyl ketimines was also evaluated and afforded 15 in 92% de. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.073
• 作为产物：
  描述：

  2-(3-溴苯基)-2-甲基-1,3-二氧戊环 在 magnesium 、 1,2-二溴乙烷 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Comparative approaches toward diamines containing spatially separated homobenzylic and benzylic nitrogen stereocenters

  摘要：

  Several synthetic strategies to diamines 1-3 are described. The optimum approach via opening of aziridine afforded 1 3 in 29-60% yield over 3-5 steps. A study on formation of the benzylic stereocenter using Toste's rhenium-catalyzed asymmetric reduction of phosphinyl ketimines was also evaluated and afforded 15 in 92% de. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.05.073

文献信息

• Coupling Reaction of Grignard Reagents with α,ω-Dibromoalkanes in the Presence of Copper(I) Bromide-HMPA:Preparation of α,ω-Bis(vinylaryl)alkanes
  作者：Jun Nishimura、Noriyuki Yamada、Yuzuru Horiuchi、Eiji Ueda、Akihiro Ohbayashi、Akira Oku

  DOI：10.1246/bcsj.59.2035

  日期：1986.6

  The coupling reaction of Grignard reagents with α,β-dibromoalkanes took place smoothly in THF/ HMPA (12:1) in the presence of a catalytic amount of copper(I) bromide and gave the products in 60–100% yields. Several α,ω-bis(vinylaryl)alkanes were prepared in reasonable yields by the application of this reaction.

  格氏试剂与 α,β-二溴烷烃的偶联反应在 THF/HMPA (12:1) 中在催化量的溴化铜 (I) 存在下顺利进行，产物产率为 60-100%。通过应用该反应，以合理的产率制备了几种 α,ω-双（乙烯基芳基）烷烃。
• NISHIMURA JUN; YAMADA NORIYUKI; HORIUCHI YUZURU; UEDA EIJI; OHBAYASHI AKI+, BULL. CHEM. SOC. JAP., 59,(1986) N 6, 2035-2037
  作者：NISHIMURA JUN、 YAMADA NORIYUKI、 HORIUCHI YUZURU、 UEDA EIJI、 OHBAYASHI AKI+

  DOI：——

  日期：——
• NISHIMURA JUN; OHBAYASHI AKIHIRO; HORIUCHI YUZURU; OKADA YUKIHIRO; YAMANA+, J. ORG. CHEM., 52,(1987) N 8, 1409-1413
  作者：NISHIMURA JUN、 OHBAYASHI AKIHIRO、 HORIUCHI YUZURU、 OKADA YUKIHIRO、 YAMANA+

  DOI：——

  日期：——
• Comparative approaches toward diamines containing spatially separated homobenzylic and benzylic nitrogen stereocenters
  作者：Michal Achmatowicz、Johann Chan、Philip Wheeler、Longbin Liu、Margaret M. Faul

  DOI：10.1016/j.tetlet.2007.05.073

  日期：2007.7

  Several synthetic strategies to diamines 1-3 are described. The optimum approach via opening of aziridine afforded 1 3 in 29-60% yield over 3-5 steps. A study on formation of the benzylic stereocenter using Toste's rhenium-catalyzed asymmetric reduction of phosphinyl ketimines was also evaluated and afforded 15 in 92% de. (c) 2007 Elsevier Ltd. All rights reserved.