3-Propylamino-propan-1-thiol | 3712-87-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Propylamino-propan-1-thiol
• 英文别名: 3-propylamino-propane-1-thiol；3-(Propylamino)propane-1-thiol
• CAS: 3712-87-6
• 化学式: C₆H₁₅NS
• mdl: MFCD19219497
• 分子量: 133.258
• InChiKey: YLBIOIADVQMNJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  13
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (3-chloro-propyl)-propyl-amine; hydrochloride 在 乙醇 、 氨 、 sodium ethanolate 、 sodium 作用下， 生成 3-Propylamino-propan-1-thiol
  参考文献：
  名称：

  An Infrared Study of Hydrogen Bonding Involving the Thiol Group¹

  摘要：

  DOI：

  10.1021/ja01611a050

文献信息

• 5,8-DIMETHYL-2-[2-(1-METHYL-4-PHENYL-1H-IMIDAZOL-2-YL)-ETHYL]-[1,2,4]TRIAZOLO[1,5-A]PYRAZINE HEMIADIPATE
  申请人：H. Lundbeck A/S

  公开号：US20200140446A1

  公开（公告）日：2020-05-07

  The present invention relates to 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate, which is non-hygroscopic. The present invention also relates to pharmaceutical compositions comprising 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate, as well as the use of 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate in therapy. The 5,8-Dimethyl-2-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate being depicted below.

  本发明涉及5,8-二甲基-2-[2-(1-甲基-4-苯基-1H-咪唑-2-基)-乙基]-[1,2,4]三唑并[1,5-a]吡嗪半己二酸盐，该化合物不吸湿。本发明还涉及含有5,8-二甲基-2-[2-(1-甲基-4-苯基-1H-咪唑-2-基)-乙基]-[1,2,4]三唑并[1,5-a]吡嗪半己二酸盐的药物组合物，以及在治疗中使用5,8-二甲基-2-[2-(1-甲基-4-苯基-1H-咪唑-2-基)-乙基]-[1,2,4]三唑并[1,5-a]吡嗪半己二酸盐。下面展示了5,8-二甲基-2-[2-(1-甲基-4-苯基-1H-咪唑-2-基)-乙基]-[1,2,4]三唑并[1,5-a]吡嗪半己二酸盐的结构。
• PROCESS FOR THE MANUFACTURE OF POLYPHENOLS
  申请人：Fetsko Stephen W.

  公开号：US20090137848A1

  公开（公告）日：2009-05-28

  An improved process for the manufacture of a polyphenol compound such as bisphenol-A by introducing into a reaction zone a phenolic compound reactant, a carbonyl compound reactant, and a catalyst promoter comprising bismethylthiopropane added to the reaction system in certain specific locations, and reacting the ingredients within the reaction zone in the presence of an acid catalyst.

  一种改进的制造多酚类化合物（如双酚-A）的工艺，通过将酚类反应物、羰基化合物反应物和催化剂促进剂（包括添加到反应系统中的双甲基硫代丙烷）引入反应区域的特定位置，并在酸性催化剂的存在下在反应区域内反应这些成分。
• Method for producing bisphenol-a
  申请人：——

  公开号：US20040030196A1

  公开（公告）日：2004-02-12

  Provided is a process for producing a bisphenol A by continuously feeding phenol and acetone into a reactor unit having at least two reaction zones connected in series. In the process, an acidic cation-exchange resin partially neutralized with a sulfur-containing nitrogen compound in from 15 to 50% of the acid site thereof is used as the catalyst, and acetone having a methanol concentration of at most 3,000 ppm is separately fed into at least two reaction zones in the reactor unit. The life of the acidic cation-exchange resin catalyst used in the process is prolonged.

  提供一种生产双酚A的方法，该方法通过连续给予苯酚和丙酮到至少有两个串联反应区的反应器单元中。在该过程中，使用部分中和含有硫的氮化合物的酸性阳离子交换树脂作为催化剂，并且将甲醇浓度不超过3,000 ppm的丙酮分别加入到反应器单元中的至少两个反应区。该过程中使用的酸性阳离子交换树脂催化剂的寿命得到延长。
• Process for producing heterocyclic compound having nitromethylene group as the side chain group
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0115323A2

  公开（公告）日：1984-08-08

  Disclosed is a process for producing a heterocyclic compound having as the side chain group a nitromethylene group of the formula: wherein Y, R, and n are as defined in the specification, which comprises reacting a 2,2-dihalonitroethylene compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

  本发明公开了一种杂环化合物的生产工艺，该杂环化合物的侧链基团是式中的一 个硝基亚甲基： 其中 Y、R 和 n 如说明书中所定义，该工艺包括使 2，2-二卤硝基乙烯化合物与 1-氨基烷硫醇化合物或其 1-N 取代衍生物反应。
• Process for producing heterocyclic compounds having nitromethylene group as the side chain group
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0135803A2

  公开（公告）日：1985-04-03

  Disclosed is a process for producing a heterocyclic compound having a nitromethylene group as the side chain, of the formula: wherein Y represents a hydrogen atom, a halogen atom or a lower alkyl group, R represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aralkyl group, an alkenyl group, an alkynyl group or an acyl group, and n represents an integer of 2, 3 or 4, which comprises reacting a 2,2,2-trihalo-1-nitroethane compound with a 1-aminoalkanethiol compound or a 1-N-substituted derivative thereof.

  本发明公开了一种以硝基亚甲基为侧链的杂环化合物的生产工艺，其式如下 其中 Y 代表氢原子、卤素原子或低级烷基，R 代表氢原子、烷基、环烷基、芳基、烯基、炔基或酰基，n 代表 2、3 或 4 的整数，该工艺包括使 2，2，2-三卤-1-硝基乙烷化合物与 1-氨基烷硫醇化合物或其 1-N-取代衍生物反应。