2-(benzyloxy)-N-(6-methoxy-4-oxo-3-(pyridin-2-ylmethyl)-3,4-dihydroquinazolin-7-yl)acetamide | 1219362-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(benzyloxy)-N-(6-methoxy-4-oxo-3-(pyridin-2-ylmethyl)-3,4-dihydroquinazolin-7-yl)acetamide
• 英文别名: N-[6-methoxy-4-oxo-3-(pyridin-2-ylmethyl)quinazolin-7-yl]-2-phenylmethoxyacetamide
• CAS: 1219362-70-5
• 化学式: C₂₄H₂₂N₄O₄
• 分子量: 430.463
• InChiKey: ZKVAWPAHFCRPKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  苄氧基乙酰氯 、 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以50.5%的产率得到2-(benzyloxy)-N-(6-methoxy-4-oxo-3-(pyridin-2-ylmethyl)-3,4-dihydroquinazolin-7-yl)acetamide
  参考文献：
  名称：

  Parallel Solution Phase Synthesis of 3,6,7−4(3H)-Quinazolinones and Evaluation of Their Antitumor Activities against Human Cancer

  摘要：

  Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against a panel of human tumor cell lines, which pointed out preliminary structure-activity relationships.

  DOI：

  10.1021/cc900173s

文献信息

• Parallel Solution Phase Synthesis of 3,6,7−4(3<i>H</i>)-Quinazolinones and Evaluation of Their Antitumor Activities against Human Cancer
  作者：Hao Wu、Xilei Xie、Gang Liu

  DOI：10.1021/cc900173s

  日期：2010.5.10

  Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against a panel of human tumor cell lines, which pointed out preliminary structure-activity relationships.