2-hydroxy-1,2-bis-(2-methoxy-phenyl)-pent-4-en-1-one | 1062158-05-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-hydroxy-1,2-bis-(2-methoxy-phenyl)-pent-4-en-1-one
• 英文别名: 2-Hydroxy-1,2-bis(2-methoxyphenyl)pent-4-en-1-one；2-hydroxy-1,2-bis(2-methoxyphenyl)pent-4-en-1-one
• CAS: 1062158-05-7
• 化学式: C₁₉H₂₀O₄
• 分子量: 312.365
• InChiKey: LTDHPXYIFWLFDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酸烯丙酯 、 2,2'-dimethoxybenzoin 在 bis(η3-allyl-μ-chloropalladium(II)) 、 potassium hydride 、 二氢二苯磷苯基-4-异丙恶唑 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以68%的产率得到2-hydroxy-1,2-bis-(2-methoxy-phenyl)-pent-4-en-1-one
  参考文献：
  名称：

  Palladium-Catalyzed C-Allylation of Benzoins and an NHC-Catalyzed Three Component Coupling Derived Thereof: Compatibility of NHC- and Pd-Catalysts

  摘要：

  A large range of benzoins was successfully applied as C-nucleophiles in the palladium-catalyzed allylic alkylation with several allyl acetates, resulting in functionalized tertiary homoallylic alcohols. A number of unsymmetrical benzoins can be coupled with high levels of regio- and chemoselectivity. Finally, the challenging compatibility of free N-heterocyclic carbenes with a palladium catalyst has been utilized in a number of metal- and organocatalyzed three-component coupling reactions.

  DOI：

  10.1021/ol801644f

文献信息

• Palladium-Catalyzed C-Allylation of Benzoins and an NHC-Catalyzed Three Component Coupling Derived Thereof: Compatibility of NHC- and Pd-Catalysts
  作者：Raphaël Lebeuf、Keiichi Hirano、Frank Glorius

  DOI：10.1021/ol801644f

  日期：2008.10.2

  A large range of benzoins was successfully applied as C-nucleophiles in the palladium-catalyzed allylic alkylation with several allyl acetates, resulting in functionalized tertiary homoallylic alcohols. A number of unsymmetrical benzoins can be coupled with high levels of regio- and chemoselectivity. Finally, the challenging compatibility of free N-heterocyclic carbenes with a palladium catalyst has been utilized in a number of metal- and organocatalyzed three-component coupling reactions.