Nγ-Methyl-brevicarin | 25978-42-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: Nγ-Methyl-brevicarin
• 英文别名: UNC10100004A；dimethyl-[4-(1-methyl-9H-β-carbolin-4-yl)-butyl]-amine；N,N-dimethyl-4-(1-methyl-9H-pyrido[3,4-b]indol-4-yl)butan-1-amine；N,N-dimethyl-4-(1-methyl-9H-pyrido[3,4-b]indol-4-yl)butan-1-aminium
• CAS: 25978-42-1
• 化学式: C₁₈H₂₃N₃
• 分子量: 281.401
• InChiKey: JOALZRPQOJNAJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  31.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases
  申请人：Higgins Jonathan

  公开号：US20130231360A1

  公开（公告）日：2013-09-05

  The present disclosure is directed to compounds of Formula (I) which are inhibitors of Haspin kinase and DYRK kinases. The compounds of the present disclosure, and compositions thereof, are useful in the treatment of disease related to Haspin kinase and DYRK kinase expression and/or activity.
• [EN] BETA-CARBOLINES AS INHIBITORS OF HASPIN AND DYRK KINASES<br/>[FR] BÊTA-CARBOLINES À TITRE D'INHIBITEURS DE KINASES HASPINE ET DYRK
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2011133795A2

  公开（公告）日：2011-10-27

  The present disclosure is directed to compounds of Formula ( I ) which are inhibitors of Haspin kinase and DYRK kinases. The compounds of the present disclosure, and compositions thereof, are useful in the treatment of disease related to Haspin kinase and DYRK kinase expression and/or activity.