(2R)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: (2R)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoic acid
• 化学式: C₁₉H₂₃FN₃O₉P
• 分子量: 487.4
• InChiKey: SOTQHJIBBYQOGX-HUPYMDEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  164
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• MATERIALS AND METHODS FOR DETERMINING DIAGNOSIS AND PROGNOSIS OF PROSTATE CANCER
  申请人：McClelland Michael

  公开号：US20110236903A1

  公开（公告）日：2011-09-29

  Materials and Methods related to diagnosing and/or determining prognosis of prostate cancer.
• [EN] D-ALANINE ESTER OF SP-NUCLEOSIDE ANALOG<br/>[FR] ESTER DE D-ALANINE D'ANALOGUE DE SP-NUCLÉOSIDE
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2014078436A1

  公开（公告）日：2014-05-22

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, provided herein is an isolated compound according to Formula Ib: or a pharmaceutically acceptable salt or solvate thereof.