[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12-(hydroxymethyl)-20-methoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12-(hydroxymethyl)-20-methoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate
• 化学式: C₃₅H₄₈ClN₃O₁₀S
• 分子量: 738.3
• InChiKey: XVGUBPZXTJWYGF-VSOBNMTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  50
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  169
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• BCMA ANTIGEN BINDING PROTEINS
  申请人：Amgen Inc.

  公开号：US20140161828A1

  公开（公告）日：2014-06-12

  The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.
• BCMA ANTIGEN BINDING PROTEINS
  申请人：AMGEN INC.

  公开号：US20150344583A1

  公开（公告）日：2015-12-03

  The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.
• US9243058B2
  申请人：——

  公开号：US9243058B2

  公开（公告）日：2016-01-26