[(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2R)-2-[acetyl(methyl)amino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(1S,2R,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2R)-2-[acetyl(methyl)amino]propanoate
• 化学式: C₃₄H₄₆ClN₃O₁₀
• 分子量: 692.2
• InChiKey: WKPWGQKGSOKKOO-BBTOUDMYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  48
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• PREPARATION OF MAYTANSINOID ESTERS
  申请人：BIO-THERA SOLUTIONS, LTD., CO.

  公开号：US20140179917A1

  公开（公告）日：2014-06-26

  Provided are efficient methods for direct coupling of a maytansinoid with a carboxylic acid to prepare a maytansinoid C-3 ester in high yield using a rare earth metal-based or trifluoromethanesulfonate-based Lewis acid catalyst and a base together with a coupling reagent. Also provided are compositions used in such methods.

  提供了一种高效的方法，用于将马坦西酮与羧酸直接偶联，以制备高产率的马坦西酮C-3酯，使用基于稀土金属或三氟甲磺酸盐的路易斯酸催化剂和碱以及偶联试剂。还提供了在这种方法中使用的组合物。
• pHLIP® targeted delivery of potent cytotoxic compounds
  申请人：Rhode Island Council on Postsecondary Education

  公开号：US20200237926A1

  公开（公告）日：2020-07-30

  The invention features a composition comprising a potent cytotoxic compound and a pHLIP® peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. pHLIP® peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
• US8889855B2
  申请人：——

  公开号：US8889855B2

  公开（公告）日：2014-11-18