[(2R)-1-[2-(dimethylamino)ethoxy-hydroxyphosphoryl]oxy-3-hydroxypropan-2-yl] 12-tert-butylsulfanyldodecanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: [(2R)-1-[2-(dimethylamino)ethoxy-hydroxyphosphoryl]oxy-3-hydroxypropan-2-yl] 12-tert-butylsulfanyldodecanoate
• 化学式: C₂₃H₄₈NO₇PS
• 分子量: 513.7
• InChiKey: ULYVPYNXZRKCHM-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  33
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• HUMANIZED ANTIBODY COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID
  申请人：Lpath, Inc.

  公开号：US20140199293A1

  公开（公告）日：2014-07-17

  Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
• NOVEL BIOACTIVE LIPID DERIVATIVES, AND METHODS OF MAKING AND USING THE SAME
  申请人：LPATH, INC.

  公开号：US20150031055A1

  公开（公告）日：2015-01-29

  Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.