8-(piperidin-4-ylmethyl)-7H-purine-2,6-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-(piperidin-4-ylmethyl)-7H-purine-2,6-diamine
• 化学式: C₁₁H₁₇N₇
• 分子量: 247.3
• InChiKey: HTOAXNRKFCOYIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS
  申请人：Univerzita palackeho V Olomouci

  公开号：EP2953951A2

  公开（公告）日：2015-12-16
• [EN] 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] DÉRIVÉS DE 6-BIARYLMÉTHYLAMINO-9-CYCLOPENTYL-9H-PURINE 2-SUBSTITUÉE, LEUR UTILISATION COMME MÉDICAMENTS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：UNIV PALACKEHO

  公开号：WO2014121764A2

  公开（公告）日：2014-08-14

  This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.