1-(4,5-Dihydroxy-3-methyloxan-2-yl)butane-2,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 1-(4,5-Dihydroxy-3-methyloxan-2-yl)butane-2,3-dione
• 英文别名: 1-(4,5-dihydroxy-3-methyloxan-2-yl)butane-2,3-dione
• 化学式: C₁₀H₁₆O₅
• 分子量: 216.23
• InChiKey: YZMISZZJRAGNEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• VACCINE FOR SHIGELLA
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Serv

  公开号：US20140242666A1

  公开（公告）日：2014-08-28

  Disclosed are immunogenic conjugates and therapeutic compositions that include such immunogenic conjugates. Also disclosed are methods of treating and/or inhibiting an Shigella sonnei infection. The disclosed immunogenic conjugates have the general structure: Pr-Sr-O—N═C-Kdo-OS wherein Pr is a carrier protein, Sr is an optional spacer moiety, Kdo is an 3-deoxy-D-manno-octulosonic acid or a derivative thereof, and OS is an oligosaccharide or polysaccharide obtained from S. sonnei . In specific examples, the immunogenic conjugates include the core oligosaccharide obtained from S. sonnei having the structure: wherein R is between 1 and 10 disaccharide repeat units. In specific examples, the disaccharide repeat unit included in the immunogenic conjugate has the structure: α-L-AltNAcA-3-β-FucNAc4N-4-.
• US9144604B2
  申请人：——

  公开号：US9144604B2

  公开（公告）日：2015-09-29