[(4E,6Z,8S,9S,10E,13S,14S,16S,17R)-8,13,14,17-tetramethoxy-4,7,10,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(4E,6Z,8S,9S,10E,13S,14S,16S,17R)-8,13,14,17-tetramethoxy-4,7,10,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
• 化学式: C₃₀H₄₂N₂O₉
• 分子量: 574.7
• InChiKey: UVJYGNZAPPBVQO-OYNDZPBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• ANTICANCER COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20160002193A1

  公开（公告）日：2016-01-07

  The invention disclosed herein relates to novel Peribysin E analogues of general formula-I. Further the invention provides simple, economical and short synthesis of Peribysin E and its analogues of Formula I, in good yield and purity leading to the identification of more potent cell adhesion inhibitors.

  本发明涉及一种通式-I的新型Peribysin E类似物。此外，本发明提供了Peribysin E及其通式I的类似物的简单、经济和短的合成方法，产率高，纯度高，从而鉴定出更有效的细胞黏附抑制剂。
• US9845302B2
  申请人：——

  公开号：US9845302B2

  公开（公告）日：2017-12-19
• [EN] ANTICANCER COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] COMPOSÉS ANTICANCÉREUX ET PROCÉDÉ DE LEUR PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014128723A2

  公开（公告）日：2014-08-28

  The invention disclosed herein relates to novel Peribysin E analogues of general formula-I. Further the invention provides simple, economical and short synthesis of Peribysin E and its analogues of Formula I, in good yield and purity leading to the identification of more potent cell adhesion inhibitors.