(1S,4R,7Z,14R,18R)-N-cyclopropylsulfonyl-14-[2-(3,3-difluoropiperidin-1-yl)-2-oxoethyl]-18-[7-methoxy-8-methyl-2-(4-propan-2-yl-1,3-thiazol-2-yl)quinolin-4-yl]oxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (1S,4R,7Z,14R,18R)-N-cyclopropylsulfonyl-14-[2-(3,3-difluoropiperidin-1-yl)-2-oxoethyl]-18-[7-methoxy-8-methyl-2-(4-propan-2-yl-1,3-thiazol-2-yl)quinolin-4-yl]oxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxamide
• 化学式: C₄₅H₅₆F₂N₆O₈S₂
• 分子量: 911.1
• InChiKey: UDMJANYPQWEDFT-JLDUXXPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  63
• 可旋转键数：
  10
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  214
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR TREATING HCV INFECTIONS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20180055824A1

  公开（公告）日：2018-03-01

  The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D   (Formula I) useful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A is Certain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.

  本公开提供了代替脂肪烷，环烷，杂环烷，杂环烷，杂-杂环烷和金属茂的化合物，其化学式为ID-M-D（化学式I），可用作抗病毒剂。在本文中披露的某些实施例中，M是一个组- P-A-P-，其中A是某些代替脂肪烷，环烷，杂环烷，杂环烷，杂-杂环烷和金属茂，是病毒复制的有效和/或选择性抑制剂，特别是丙型肝炎病毒复制的抑制剂。本公开还提供了含有一个或多个代替脂肪烷，环烷，杂环烷，杂环烷，杂-杂环烷和金属茂以及药学上可接受的载体的制药组合物/和组合物。本公开还提供了用于治疗病毒感染，包括丙型肝炎病毒感染的方法。
• Chimeric antigen receptor (CAR) modulation
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US11059864B2

  公开（公告）日：2021-07-13

  The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.

  本文所述技术针对的是包含可抑制蛋白酶的 CAR 多肽和系统。结合特定的蛋白酶抑制剂，可以调节所述 CAR 多肽和系统以及包含它们的细胞的活性。本文还描述了使用所述 CAR 多肽和系统的方法，例如用于治疗各种疾病和失调。
• Regulated synthetic gene expression systems
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US11530246B2

  公开（公告）日：2022-12-20

  The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.

  本文所述技术针对的是受调控的合成基因表达系统。一方面，本文所述的合成转录因子（synTFs）包括 DNA 结合结构域、转录效应结构域和调节蛋白。在其他方面，本文所述的基因表达系统包括所述的合成转录因子和使用所述合成转录因子治疗疾病和失调的方法。
• 4-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：EP2364310B1

  公开（公告）日：2015-07-29
• CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US20200308234A1

  公开（公告）日：2020-10-01

  The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.