1-Methoxy-2,4,8-trimethylphenothiazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 1-Methoxy-2,4,8-trimethylphenothiazin-3-one
• 英文别名: 1-methoxy-2,4,8-trimethylphenothiazin-3-one
• 化学式: C₁₆H₁₅NO₂S
• 分子量: 285.4
• InChiKey: UNOVNKJBZWHVME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• US20140275045A1
  申请人：——

  公开号：US20140275045A1

  公开（公告）日：2014-09-18
• PHENAZINE-3-ONE AND PHENOTHIAZINE-3-ONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS
  申请人：EDISON PHARMACEUTICALS, INC.

  公开号：US20160039776A1

  公开（公告）日：2016-02-11

  Disclosed herein are phenazine-3-one and phenothiazine-3-one derivative compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging.
• THERAPEUTIC COMPOSITIONS INCLUDING PHENAZINE-3-ONE AND PHENOTHIAZINE-3-ONE DERIVATIVES AND USES THEREOF
  申请人：Stealth BioTherapeutics Corp

  公开号：US20160228491A1

  公开（公告）日：2016-08-11

  Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of phenazine-3-one and/or phenothiazine-3-one derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to phenazine-3-one or phenothiazine-3-one derivatives and uses of the same. In some embodiments, the aromatic-cationic peptide comprises D-Arg-2′6′-Dmt-Lys-Phe-NH 2 .
• US9868711B2
  申请人：——

  公开号：US9868711B2

  公开（公告）日：2018-01-16