6-Methyl-9-propan-2-ylpurin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-Methyl-9-propan-2-ylpurin-2-amine
• 英文别名: 6-methyl-9-propan-2-ylpurin-2-amine
• 化学式: C₉H₁₃N₅
• 分子量: 191.23
• InChiKey: OMJGYKSNJIARFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
  申请人：ALIOS BIOPHARMA, INC.

  公开号：US20170037075A1

  公开（公告）日：2017-02-09

  Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

  本文揭示了核苷酸类似物、合成核苷酸类似物的方法以及使用一个或多个核苷酸类似物治疗HCV感染等疾病和/或状况的方法。
• AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS
  申请人：Alios BioPharma, Inc.

  公开号：US20160264610A1

  公开（公告）日：2016-09-15

  Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

  本文披露了核苷、核苷酸及其类似物、包含一个或多个核苷、核苷酸及其类似物的制药组合物，以及它们的合成方法。本文还披露了使用核苷、核苷酸和其类似物改善和/或治疗疾病和/或病况的方法，包括来自副黏病毒和/或正黏病毒的感染。病毒感染的例子包括呼吸道合胞病毒（RSV）和流感感染。
• AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV
  申请人：Centre National De La Recherche Scientifique

  公开号：US20160113956A1

  公开（公告）日：2016-04-28

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R 1 and R 2 are as described herein.

  本文提供了治疗黄病毒科感染，包括丙型肝炎（HCV）感染的化合物、组合物和方法。在某些实施例中，揭示了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。在某些实施例中，所述化合物是根据公式1001或2001的2'-氰基，偶氮基或氨基核苷衍生物，或其药学上可接受的盐，溶剂化合物，立体异构体，互变异构体或多态形式，其中Base，W，R1和R2如本文所述。
• Inhibitors of human phosphatidylinositol 3-kinase delta
  申请人：ICOS CORPORATION

  公开号：US10398695B2

  公开（公告）日：2019-09-03

  Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.

  本发明公开了抑制磷脂酰肌醇 3- 激酶δ异构体（PI3Kδ）活性的方法，以及治疗 PI3Kδ 在白细胞功能中发挥作用的疾病（如免疫和炎症紊乱）的方法。优选地，这些方法采用的活性剂可选择性地抑制 PI3Kδ，同时不会明显抑制其他 PI3K 同工酶的活性。提供了抑制 PI3Kδ 活性的化合物，包括选择性抑制 PI3Kδ 活性的化合物。还提供了使用 PI3Kδ 抑制性化合物抑制癌细胞生长或增殖的方法。因此，本发明提供了使用 PI3Kδ 抑制性化合物抑制体外和体内 PI3Kδ 介导过程的方法。
• US20140271547A1
  申请人：——

  公开号：US20140271547A1

  公开（公告）日：2014-09-18