(1S,2R,5S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (1S,2R,5S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione
• 化学式: C₂₈H₃₇ClN₂O₇
• 分子量: 549.1
• InChiKey: MJEKMYYSIWOILD-IKJOMYBPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  38
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
  申请人：Redwood Bioscience, Inc.

  公开号：US10604483B2

  公开（公告）日：2020-03-31

  The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

  本公开提供了共轭结构和用于生产这些共轭物的肼基-吡咯化合物结构。本公开还包括生产这种共轭物的方法以及使用这种共轭物的方法。
• Hydrazinyl-Pyrrolo Compounds and Methods for Producing a Conjugate
  申请人：Redwood Bioscience, Inc.

  公开号：US20200317610A1

  公开（公告）日：2020-10-08

  The present disclosure provides conjugate structures and hydrazinyl-pyrrolo compound structures used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.
• [EN] BIOLOGICALLY ACTIVE MOLECULES, CONJUGATES THEREOF, AND THERAPEUTIC USES<br/>[FR] MOLÉCULES BIOLOGIQUEMENT ACTIVES, LEURS CONJUGUÉS, ET UTILISATIONS THÉRAPEUTIQUES
  申请人：REGENERON PHARMA

  公开号：WO2014145090A1

  公开（公告）日：2014-09-18

  The present disclosure relates to linker compounds that are useful in covalently linking biologically active molecules with Ligands. The disclosed compounds also relate to biologically active molecules and Ligand conjugates, wherein the biologically active molecule is linked to the Ligand through a linker. The disclosure further provides compositions comprising biologically active molecule -ligand conjugates, methods of modifying abnormal cell growth and methods of treatment using the conjugates or the compositions.