carbazole picrate | 24171-69-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: carbazole picrate
• 英文别名: 2,4,6-Trinitrophenol-9h-carbazole(1:1)；9H-carbazole;2,4,6-trinitrophenol
• CAS: 24171-69-5
• 化学式: C₆H₃N₃O₇*C₁₂H₉N
• 分子量: 396.316
• InChiKey: FADRGCWXNPAFBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  174
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  咔唑 、 苦味酸 以 甲醇 为溶剂， 反应 72.0h， 生成 carbazole picrate
  参考文献：
  名称：

  Synthesis, spectroscopic characterization and structural investigations of new adduct compound of carbazole with picric acid: DNA binding and antimicrobial studies

  摘要：

  Carbazole picrate (CP), a new organic compound has been synthesized, characterized by various analytical and spectroscopic technique such as FT-IR, UV-Vis, H-1 and C-13 NMR spectroscopy. An orthorhombic geometry was proposed based on single crystal XRD study. The thermal stability of the crystal was studied by using thermo-gravimetric and differential thermal analyses and found that it was stable up to 170 degrees C. Further, the newly synthesized title compound was tested for its in vitro antibacterial and antifungal activity against various bacterial and fungal species. Also, the compound was tested for its binding activity with Calf thymus (CT) DNA and the results show a considerable interaction between CP and CT-DNA. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2013.08.115

文献信息

• Synthesis, spectroscopic characterization and structural investigations of new adduct compound of carbazole with picric acid: DNA binding and antimicrobial studies
  作者：Munusamy Saravanabhavan、Krishnan Sathya、Vedavati G. Puranik、Marimuthu Sekar

  DOI：10.1016/j.saa.2013.08.115

  日期：2014.1

  Carbazole picrate (CP), a new organic compound has been synthesized, characterized by various analytical and spectroscopic technique such as FT-IR, UV-Vis, H-1 and C-13 NMR spectroscopy. An orthorhombic geometry was proposed based on single crystal XRD study. The thermal stability of the crystal was studied by using thermo-gravimetric and differential thermal analyses and found that it was stable up to 170 degrees C. Further, the newly synthesized title compound was tested for its in vitro antibacterial and antifungal activity against various bacterial and fungal species. Also, the compound was tested for its binding activity with Calf thymus (CT) DNA and the results show a considerable interaction between CP and CT-DNA. (C) 2013 Elsevier B.V. All rights reserved.