4-<2-Hydroxy-aethylamino>-2-oxo-6.7-dimethyl-dihydropteridin | 90973-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 4-<2-Hydroxy-aethylamino>-2-oxo-6.7-dimethyl-dihydropteridin
• 英文别名: 4-(2-hydroxy-ethylamino)-6,7-dimethyl-1H-pteridin-2-one；4-(2-Hydroxy-ethylamino)-6,7-dimethyl-1H-pteridin-2-one；4-(2-hydroxyethylamino)-6,7-dimethyl-1H-pteridin-2-one
• CAS: 90973-31-2
• 化学式: C₁₀H₁₃N₅O₂
• 分子量: 235.246
• InChiKey: IWIJQBBVAJBJOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  99.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-hydroxy-4-mercapto-6,7-dimethylpteridine 、 C.I.酸性橙108 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以60%的产率得到4-<2-Hydroxy-aethylamino>-2-oxo-6.7-dimethyl-dihydropteridin
  参考文献：
  名称：

  Syntheses of novel heterocycles as anticancer agents

  摘要：

  Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCl-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as new leads in cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.02.055

文献信息

• Syntheses of novel heterocycles as anticancer agents
  作者：Prem M.S. Chauhan、Cristina J.A. Martins、David C. Horwell

  DOI：10.1016/j.bmc.2005.02.055

  日期：2005.5

  Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCl-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as new leads in cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.