(1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl)amine | 1123230-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl)amine
• 英文别名: 1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-amine；1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-amine；1-(4-naphthalen-2-ylpyrimidin-2-yl)piperidin-4-amine
• CAS: 1123230-88-5
• 化学式: C₁₉H₂₀N₄
• 分子量: 304.395
• InChiKey: VXWSVKIOGWIDKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氨基哌啶 、 2-chloro-4-[2-naphthyl]pyrimidine 在 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以69%的产率得到(1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl)amine
  参考文献：
  名称：

  (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate

  摘要：

  A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt beta-catenin cellular messaging system. Hit-to-lead in vitro optimization for target activity and molecular properties led to the discovery of (1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine (5, WAY-262611). Compound 5 has excellent pharmacokinetic properties and showed a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration.

  DOI：

  10.1021/jm9014197

文献信息

• NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM
  申请人：Pelletier Jeffrey Claude

  公开号：US20090054392A1

  公开（公告）日：2009-02-26

  The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.

  本发明涉及萘基嘧啶类似物、制备萘基嘧啶类似物的方法、包含萘基嘧啶类似物的组合物以及治疗与经典Wnt-β-catenin细胞信息传递系统相关的疾病的方法，包括向需要治疗的受试者投予有效量的萘基嘧啶、萘基吡嗪和萘基吡啶类似物。
• Ester diol alkoxylate based alkyd resins and compositions containing them
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0040979A2

  公开（公告）日：1981-12-02

  An alkyd resin characterised in that it comprises the reaction product of (A) an ester diol alkoxylate of the formula wherein m is an integer having a value of from 2 to 4, n is an integer having a value of from 1 to 5, x and y are integers each having a value of from 1 to 20, and R is an unsubstituted or substituted alkyl group having from 1 to 8 carbon atoms with (B) a polyol and (C) a polycarboxylic acid or anhydride thereof. A coating composition comprising such a resin and the coating composition when cured.

  一种醇酸树脂，其特征在于它由以下物质的反应产物组成 (A) 式中的酯二醇烷氧基化物 其中 m 是 2 至 4 的整数，n 是 1 至 5 的整数，x 和 y 分别是 1 至 20 的整数，R 是具有 1 至 8 个碳原子的未取代或取代的烷基。 一种涂料组合物，包括这种树脂和固化后的涂料组合物。
• BIOLOGICAL ACTIVE COATING COMPONENTS, COATINGS, AND COATED SURFACES
  申请人：McDaniel, Steven C.

  公开号：EP1551927A1

  公开（公告）日：2005-07-13
• PRIMER COMPOSITIONS FOR ADHESIVE BONDING SYSTEMS AND COATINGS
  申请人：Henkel AG & Co. KGaA

  公开号：EP2190900A2

  公开（公告）日：2010-06-02
• US9522974B2
  申请人：——

  公开号：US9522974B2

  公开（公告）日：2016-12-20