4-(3,4-dimethylnaphthalen-1-yl)morpholine | 1365911-32-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(3,4-dimethylnaphthalen-1-yl)morpholine
• 英文别名: 4-(3,4-Dimethylnaphthalen-1-yl)morpholine
• CAS: 1365911-32-5
• 化学式: C₁₆H₁₉NO
• 分子量: 241.333
• InChiKey: PPHSDPWTUPNBSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吗啉 、 1-氯甲基-2-甲基萘 在 sodium hydride 、 四(三苯基膦)钯 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 16.03h， 以78%的产率得到4-(3,4-dimethylnaphthalen-1-yl)morpholine
  参考文献：
  名称：

  Palladium-Catalyzed Amination of Chloromethylnaphthalene and Chloromethylanthracene Derivatives with Various Amines

  摘要：

  Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives to produce naphthylamines and anthrylamines in satisfactory to good yields has been developed. The unprecedented amination reactions proceeded smoothly under mild conditions in the presence of Pd(PPh3)(4) as a catalyst.

  DOI：

  10.1021/ja300164d

文献信息

• Palladium-Catalyzed Amination of Chloromethylnaphthalene and Chloromethylanthracene Derivatives with Various Amines
  作者：Sheng Zhang、Yi Wang、Xiujuan Feng、Ming Bao

  DOI：10.1021/ja300164d

  日期：2012.3.28

  Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives to produce naphthylamines and anthrylamines in satisfactory to good yields has been developed. The unprecedented amination reactions proceeded smoothly under mild conditions in the presence of Pd(PPh3)(4) as a catalyst.