1-(2-methyl-[1]naphthylmethyl)-pyridinium; chloride | 98029-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-methyl-[1]naphthylmethyl)-pyridinium; chloride
• 英文别名: 1-[(2-Methylnaphthalen-1-yl)methyl]pyridin-1-ium;chloride
• CAS: 98029-29-9
• 化学式: C₁₇H₁₆N*Cl
• 分子量: 269.774
• InChiKey: XPYWZTHUKCEFGJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.49
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  吡啶 、 1-氯甲基-2-甲基萘 在 乙醚 作用下， 生成 1-(2-methyl-[1]naphthylmethyl)-pyridinium; chloride
  参考文献：
  名称：

  Caloric restriction restores the cardioprotective effect of preconditioning in the rat heart

  摘要：

  Preconditioning (PC) describes the observation that brief periods of ischemia paradoxically protect the heart and limit necrosis caused by a subsequent more prolonged period of ischemia. However, the PC response is attenuated in hearts from 9- to 12-month-old Sprague-Dawley rats, as compared to young adults. This study determined whether long-term caloric restriction (CR) could preserve the PC response, since CR increases ischemic tolerance in these hearts. Following 6 months of CR, isolated hearts underwent PC followed by ischemia and reperfusion. In contrast to control hearts in which PC response was attenuated, PC in CR hearts was clearly of benefit. In these hearts, aortic flow was increased resulting in a dramatic improvement of cardiac output. Our study suggests that CR is effective in preserving the PC response. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

  DOI：

  10.1016/s0047-6374(02)00068-4

文献信息

• Caloric restriction restores the cardioprotective effect of preconditioning in the rat heart
  作者：Paige Long、Quang Nguyen、Chantelle Thurow、Tom L Broderick

  DOI：10.1016/s0047-6374(02)00068-4

  日期：2002.7

  Preconditioning (PC) describes the observation that brief periods of ischemia paradoxically protect the heart and limit necrosis caused by a subsequent more prolonged period of ischemia. However, the PC response is attenuated in hearts from 9- to 12-month-old Sprague-Dawley rats, as compared to young adults. This study determined whether long-term caloric restriction (CR) could preserve the PC response, since CR increases ischemic tolerance in these hearts. Following 6 months of CR, isolated hearts underwent PC followed by ischemia and reperfusion. In contrast to control hearts in which PC response was attenuated, PC in CR hearts was clearly of benefit. In these hearts, aortic flow was increased resulting in a dramatic improvement of cardiac output. Our study suggests that CR is effective in preserving the PC response. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.