8-[(2-Chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluoro-9-pentylpurin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-[(2-Chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluoro-9-pentylpurin-6-amine
• 英文别名: 8-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluoro-9-pentylpurin-6-amine
• 化学式: C₂₀H₂₅ClFN₅O₃
• 分子量: 437.9
• InChiKey: AMOYRZZFWVHRNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• EPICHAPEROME INHIBITOR THERAPY FOR TRAUMATIC BRAIN INJURY AND SEQUELAE THEREOF
  申请人：Samus Therapeutics, Inc

  公开号：US20210161902A1

  公开（公告）日：2021-06-03

  Provided herein are methods of using certain Hsp90 inhibitors in treating subjects who have experienced or are experiencing a traumatic brain injury, including lessening the short term impact of such TBI and/or reducing the risk of developing and/or the severity of long term after effects of such TBI.