1-(9,10-dichlorobenzo[a]phenazin-5-yl)naphthalen-2-ol | 1311158-21-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(9,10-dichlorobenzo[a]phenazin-5-yl)naphthalen-2-ol
• 英文别名: 1-(9,10-Dichlorobenzo[a]phenazin-5-yl)naphthalen-2-ol
• CAS: 1311158-21-0
• 化学式: C₂₆H₁₄Cl₂N₂O
• 分子量: 441.316
• InChiKey: JVPDZNVOAZMPMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,5-二氯邻苯二胺 、 2-萘酚 在 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 32.0h， 以9%的产率得到9,10-dichlorobenzo[a]phenazine
  参考文献：
  名称：

  A New Class of Phenazines with Activity against a Chloroquine Resistant Plasmodium falciparum Strain and Antimicrobial Activity

  摘要：

  New phenazines were synthesized by oxygenation of 1- and 2-naphthol with transition metal peroxo complexes and in situ reaction with 1,2-diamines. The title compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum and chloroquine-resistant strains. Phenazines 12, 27, and 28 were most prominent in growth inhibition. In vivo protection against cerebral malaria was observed with the phenazines 11, 12, 20, and 27, whereas partial protection was provided by 19.

  DOI：

  10.1021/jm200302d

文献信息

• A New Class of Phenazines with Activity against a Chloroquine Resistant <i>Plasmodium falciparum</i> Strain and Antimicrobial Activity
  作者：Hidayat Hussain、Sabine Specht、Salem R. Sarite、Michael Saeftel、Achim Hoerauf、Barbara Schulz、Karsten Krohn

  DOI：10.1021/jm200302d

  日期：2011.7.14

  New phenazines were synthesized by oxygenation of 1- and 2-naphthol with transition metal peroxo complexes and in situ reaction with 1,2-diamines. The title compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum and chloroquine-resistant strains. Phenazines 12, 27, and 28 were most prominent in growth inhibition. In vivo protection against cerebral malaria was observed with the phenazines 11, 12, 20, and 27, whereas partial protection was provided by 19.