{(S)-2-[(2S,4R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester | 200623-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: {(S)-2-[(2S,4R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
• 英文别名: 9H-fluoren-9-ylmethyl N-[(2S)-1-[(2S,4R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(diphenyl)silyl]oxypyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate
• CAS: 200623-13-8
• 化学式: C₆₀H₆₂N₂O₇Si
• 分子量: 951.247
• InChiKey: OSUUIQVSAXEQAD-VHYHSRQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.49
• 重原子数：
  70
• 可旋转键数：
  18
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  {(S)-2-[(2S,4R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 在 哌啶 、 potassium carbonate 、 苯硫酚 、 三乙胺 、 N,N-二异丙基乙胺 、 乙酰氯 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  The solid phase synthesis of trisubstituted 1,4-diazabicyclo[4.3.0]nonan-2-one scaffolds: On bead monitoring of heterocycle forming reactions using 15N NMR

  摘要：

  Several representative 3,4,8-trisubstituted 1,4-diazabicyclo[3.4.0]nonan-2-ones have been prepared employing solid phase methodologies. Elaboration of a 4-hydroxyproline derivative with an N-15-amino acid derivative allowed convenient monitoring of the reaction sequence on solid support by gel-phase N-15 NMR. An intramolecular Mitsunobu cyclization provided the desired heterocycle, which could be further functionalized at the 4-position. This synthetic method is facile, general, and suitable for the construction of large libraries of compounds for biological assays. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10375-6
• 作为产物：
  描述：

  9-fluorenylmethyloxycarbonyl-5-(4,4'dimethoxytrityloxy)methyl-3-hydroxypyrrolidine 在 哌啶 、 咪唑 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 {(S)-2-[(2S,4R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-diphenyl-silanyloxy)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  The solid phase synthesis of trisubstituted 1,4-diazabicyclo[4.3.0]nonan-2-one scaffolds: On bead monitoring of heterocycle forming reactions using 15N NMR

  摘要：

  Several representative 3,4,8-trisubstituted 1,4-diazabicyclo[3.4.0]nonan-2-ones have been prepared employing solid phase methodologies. Elaboration of a 4-hydroxyproline derivative with an N-15-amino acid derivative allowed convenient monitoring of the reaction sequence on solid support by gel-phase N-15 NMR. An intramolecular Mitsunobu cyclization provided the desired heterocycle, which could be further functionalized at the 4-position. This synthetic method is facile, general, and suitable for the construction of large libraries of compounds for biological assays. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10375-6

文献信息

• The solid phase synthesis of trisubstituted 1,4-diazabicyclo[4.3.0]nonan-2-one scaffolds: On bead monitoring of heterocycle forming reactions using 15N NMR
  作者：Eric E. Swayze

  DOI：10.1016/s0040-4039(97)10375-6

  日期：1997.12

  Several representative 3,4,8-trisubstituted 1,4-diazabicyclo[3.4.0]nonan-2-ones have been prepared employing solid phase methodologies. Elaboration of a 4-hydroxyproline derivative with an N-15-amino acid derivative allowed convenient monitoring of the reaction sequence on solid support by gel-phase N-15 NMR. An intramolecular Mitsunobu cyclization provided the desired heterocycle, which could be further functionalized at the 4-position. This synthetic method is facile, general, and suitable for the construction of large libraries of compounds for biological assays. (C) 1997 Published by Elsevier Science Ltd.