3-ethoxycarbonyl-7,8-difluoro-1-methoxy-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine | 132669-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-ethoxycarbonyl-7,8-difluoro-1-methoxy-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine
• 英文别名: 3-Ethoxycarbonyl-7,8-difluoro-1-methoxy-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine；ethyl 7,8-difluoro-1-methoxy-4-oxobenzo[b][1,8]naphthyridine-3-carboxylate
• CAS: 132669-29-5
• 化学式: C₁₆H₁₂F₂N₂O₄
• 分子量: 334.279
• InChiKey: YQFHWOYGEWHBRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  3-ethoxycarbonyl-7,8-difluoro-1-methoxy-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine 在 溶剂黄146 作用下， 以 N-甲基乙酰胺 、 盐酸 、 乙醇 、 水 为溶剂， 生成 7,8-difluoro-1-methoxy-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  Benzo(1,8)naphthyridine derivatives as intermediates

  摘要：

  通用公式（I）的新苯并[b][1,8]萘啉衍生物，其中R是氢原子或烷基、氟烷基、环烷基（3到6个碳原子）、烷氧基、烷基氨基或保护的烷基氨基基团，Hal是F、Cl或Br，如果R'是氢，则Hal和R'是F，Alk是烷基基团，以及它们的制备。这些新产品可用作制备生物活性产物的中间体。

  公开号：

  US04970213A1
• 作为产物：
  描述：

  ethyl 2-(2-chloro-6,7-difluoro-3-quinolinecarbonyl)-3-(dimethylamino)-acrylate 、 甲氧基胺盐酸盐 在 三乙胺 作用下， 以 乙醇 、 氯仿 为溶剂， 生成 3-ethoxycarbonyl-7,8-difluoro-1-methoxy-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine
  参考文献：
  名称：

  Benzo(1,8)naphthyridine derivatives as intermediates

  摘要：

  通用公式（I）的新苯并[b][1,8]萘啉衍生物，其中R是氢原子或烷基、氟烷基、环烷基（3到6个碳原子）、烷氧基、烷基氨基或保护的烷基氨基基团，Hal是F、Cl或Br，如果R'是氢，则Hal和R'是F，Alk是烷基基团，以及它们的制备。这些新产品可用作制备生物活性产物的中间体。

  公开号：

  US04970213A1

文献信息

• Benzo[1,8]naphthyridine derivatives, their preparation and compositions
  申请人：Laboratoire Roger Bellon

  公开号：US05053509A1

  公开（公告）日：1991-10-01

  New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R.sub.1 is a hydrogen atom or a hydroxyl or alkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R.sub.3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R.sub.3 is a heterocyclic radical, and R.sub.4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them. These new products are useful as antimicrobials, or in the treatment of AIDS. ##STR1##

  新的苯并[b][1,8]萘啉衍生物的一般式(I)，其中R.sub.1是氢原子或羟基或烷基基团，R.sub.2是氢原子或烷基、氟烷基、环烷基（3至6个碳）、烷氧基或烷基氨基基团，R.sub.3是苯基或苯基烷基基团，其上取代有一个或多个卤素原子或烷基、环烷基（3至6个碳）、烷氧基、氰基、氨基、烷基氨基、二烷基氨基、烷氧基烷基、羟基烷基、羟基烷氧基、亚甲二氧基、氨基烷基、烷基氨基烷基或二烷基氨基烷基基团，或R.sub.3是杂环基团，R.sub.4是氢原子或氟原子，烷基基团（1至4个碳）为直链或支链，它们的盐、它们的制备和含有它们的组合物。这些新产品可用作抗微生物药物，或用于治疗艾滋病。
• 1,8 benzonaphthyridine derivatives and antimicrobial compositions
  申请人：Laboratoire Roger Bellon

  公开号：US05556861A1

  公开（公告）日：1996-09-17

  This invention relates to a novel 1,8 benzo[b]naphythyridine derivative of general formula (I), ##STR1## wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C.sub.3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R.sub.1 and R.sub.2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C.sub.2-4 alkenyl, phenyl, or substituted phenyl, or R.sub.1 and R.sub.2 are in position 2 and represent alkyl; R.sub.3 is H or alkyl, fluoroalkyl, carboxyalkyl, C.sub.3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R.sub.4 is H or F, wherein the C.sub.1-4 alkanyl and alkyl radicals are linear or branched; stereoisomeric forms thereof or mixtures of these; and salts and hydrated forms thereof. These novel derivatives are useful as antimicrobials.

  这项发明涉及一种新型1,8-苯并[b]萘啉衍生物，其通式为(I)，其中R为H或一个羟基、氨基或烷基氨基基团，该基团可选择通过氨基或羟基进行取代，或R为二烷基氨基，其中烷基部分可以与氮原子形成一个含有氮、氧或硫的5-或6-成员杂环环，或R为C.sub.3-6环烷基氨基或烷基氨基，N-烷基N-烷基烷氨基或氨基烷基苯氨基基团；R.sub.1和R.sub.2在2和3位置，代表H、烷基、C.sub.2-4烯基、苯基或取代苯基，或R.sub.1和R.sub.2在2位置，代表烷基；R.sub.3为H或烷基、氟烷基、羧基烷基、C.sub.3-6环烷基、氟苯基、二氟苯基、烷氧基或烷基氨基；R.sub.4为H或F，其中C.sub.1-4烷基和烷基基团为直链或支链；其立体异构体形式或这些形式的混合物；以及其盐和水合形式。这些新型衍生物可用作抗微生物药物。
• Benzo[1,8]naphthyridine derivatives as antimicrobials
  申请人：Rhone-Poulenc Sante

  公开号：US04990515A1

  公开（公告）日：1991-02-05

  New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy or alkylamino radical or an amine protective radical and either Hal is a fluorine, chlorine or bromine atom and R' is a hydrogen atom or Hal and R' are simultaneously fluorine atoms, their salts, their preparation and the compositions which contain them. These new products can be used as antimicrobial agents for topical application or as synthesis intermediates. ##STR1##

  通式（I）中的新苯并[b][1,8]萘啉衍生物，其中R是氢原子或烷基，氟烷基，环烷基（3到6 C），烷氧基或烷基氨基基团或胺保护基团，而Hal是氟，氯或溴原子，R'是氢原子或Hal，R'同时是氟原子，它们的盐，它们的制备和包含它们的组合物。这些新产品可用作局部应用的抗微生物剂或合成中间体。 ##STR1##
• Benzo[1,8]naphthyridine derivatives, their preparation and the
  申请人：Laboratoire Roger Bellon

  公开号：US05004745A1

  公开（公告）日：1991-04-02

  New benzo[b][1,8]naphthyridine derivatives of general formula (I) in which R.sub.1 is a hydrogen atom or an alkyl or hydroxyalkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkoxy or alkylamino radical and R.sub.3 is alkyl, R.sub.4 and R.sub.5 are different and are hydrogen or alkyl, or R.sub.3 is H, alkyl or cycloalkyl and R.sub.4 and R.sub.5 are hydrogen, R.sub.6 is hydrogen or fluorine and n is equal to 1 or 2, their salts, their preparation and the compositions which contain them. These new products are used as antimicrobial agents ##STR1##

  新的苯并[b][1,8]萘啉衍生物的一般式(I)，其中R.sub.1是氢原子或烷基或羟基烷基基团，R.sub.2是氢原子或烷基，氟代烷基，环烷基(3到6个碳原子)，烷氧基或烷基氨基基团，R.sub.3是烷基，R.sub.4和R.sub.5不同，是氢或烷基，或R.sub.3是H，烷基或环烷基，R.sub.4和R.sub.5是氢，R.sub.6是氢或氟，n等于1或2，它们的盐，它们的制备和包含它们的组合物。这些新产品用作抗微生物剂。##STR1##
• ANTOINE, MICHEL;BARREAU, MICHEL;DESCONCLOIS, JEAN-FRANCOIS;GIRARD, PHILIP+
  作者：ANTOINE, MICHEL、BARREAU, MICHEL、DESCONCLOIS, JEAN-FRANCOIS、GIRARD, PHILIP+

  DOI：——

  日期：——