N-(9H-fluorenylmethoxycarbonyloxy)succinimide | 213322-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-(9H-fluorenylmethoxycarbonyloxy)succinimide
• 英文别名: Fmoc-O-succinimide；Fmoc-OSu；fluorenylmethyl N-succinimidyl carbonate；N-(fluorenylmethoxycarbonyloxy)succinimide；fluorenylmethyl succinimidyl carbonate；(2,5-dioxopyrrolidin-1-yl) 9H-fluoren-1-ylmethyl carbonate
• CAS: 213322-15-7
• 化学式: C₁₉H₁₅NO₅
• 分子量: 337.332
• InChiKey: OCGHJDIGJXZRIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(9H-fluorenylmethoxycarbonyloxy)succinimide 在 碳酸氢钠 作用下， 生成 (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-((2-hydroxyethoxy)methyl)propanoic acid
  参考文献：
  名称：

  AMINO ACID HAVING FUNCTIONAL GROUP CAPABLE OF INTERMOLECULAR HYDROGEN BONDING, PEPTIDE COMPOUND CONTAINING SAME AND METHOD FOR PRODUCTION THEREOF

  摘要：

  It has been found that the membrane permeability of peptide compounds can be improved by making at least one of amino acids constituting the peptide compound be an amino acid having a side chain capable of forming an intramolecular hydrogen bond.

  公开号：

  US20230096766A1

文献信息

• HIV protease inhibiting compounds
  申请人：DeGoey A. David

  公开号：US20050148623A1

  公开（公告）日：2005-07-07

  A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

  披露了一种公式的化合物作为HIV蛋白酶抑制剂。还披露了用于抑制HIV感染的方法和组合物。
• Amphiphilic cyclodextrin derivatives, method for preparation thereof and uses thereof
  申请人：Perly Bruno

  公开号：US20070142324A1

  公开（公告）日：2007-06-21

  The invention relates to cyclodextrin derivatives of formula (I): in which: R 1 ═—NH-E-AA-(L 1 ) p (L 2 ) q where E=a linear or branched Cl-Cl 5 hydrocarbon-based group with, optionally, one or more hetero atoms; AA=the residue of an amino acid; L 1 and L 2 =a C 6 -C 24 hydrocarbon-based group with, optionally, one or more hetero atoms; p and q=0 or 1, at least one being ≠0; R 2 ═H, —CH 3 , isopropyl, hydroxypropyl, sulphobutyl ether; R 3 ═H or R 2 , except when R 2 =hydroxypropyl; all the R 4 ═—OH or R 2 , except when R 2 =hydroxypropyl, or at least one of the R 4 ═R 1 ; n=5, 6 or 7. The invention also relates to a process for preparing them, and to inclusion complexes and organized surfactant systems comprising them.

  该发明涉及以下式（I）的环糊精衍生物： 其中： R 1 ═—NH-E-AA-(L 1 ) p (L 2 ) q 其中E=线性或支链的Cl-Cl 5 碳氢基团，可选地，含有一个或多个杂原子；AA=氨基酸的残基；L 1 和L 2 =含有一个或多个杂原子的C 6 -C 24 碳氢基团；p和q=0或1，至少一个不等于0； R 2 ═H，—CH 3 ，异丙基，羟丙基，磺丁基醚； R 3 ═H或R 2 ，除非R 2 =羟丙基； 所有的R 4 ═—OH或R 2 ，除非R 2 =羟丙基，或者至少一个R 4 ═R 1 ；n=5、6或7。该发明还涉及一种制备它们的方法，以及包含它们的包合物和有序表面活性剂系统。
• Synthesis of α-N-Linked Glycopeptides
  作者：Cinzia Colombo、Anna Bernardi

  DOI：10.1002/ejoc.201100124

  日期：2011.7

  A practical synthesis of Nα-fluorenylmethoxycarbonyl-Nγ-(2,3,4,6-tetra-O-acetyl-α-D-glycopyranosyl)-L-asparagine in the gluco and galacto series has been achieved by using the methodology developed by DeShong and co-workers. The resulting α-N-linked glycosyl amino acids were used in a linear approach to the synthesis of glycopeptides featuring the unnatural α-N-glycosyl linkage. Activation conditions

  Nα-芴基甲氧基羰基-Nγ-(2,3,4,6-四-O-乙酰基-α-D-吡喃糖基)-L-天冬酰胺在葡萄糖和半乳糖系列中的实际合成已通过使用开发的方法实现德松和同事们。得到的 α-N-连接的糖基氨基酸用于以线性方法合成具有非天然 α-N-糖基连接的糖肽。已经定义了溶液中 C 端和 N 端伸长的活化条件。遇到的主要副反应是在 C 端延伸期间由活化的氨基酸形成环化副产物（天冬氨酸）。确定了合适的缩合剂，其允许高产率的二肽形成并且没有糖基氨基酸的差向异构化。糖脱乙酰的条件也得到了优化。探索了固相合成（Fmoc 协议）条件，发现 PyBROP 是糖基氨基酸激活的首选试剂。因此，合成更复杂的 α-N 连接糖肽变得可行，这将允许研究这些新糖缀合物的特性。
• Topologically segregated, encoded solid phase libraries
  申请人：Selectide Corporation

  公开号：US05840485A1

  公开（公告）日：1998-11-24

  The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

  本发明涉及合成测试化合物的文库，其附着于分离相合成支持物上，还包含编码分子，用于编码合成测试化合物的结构。这些分子可以是聚合物或多个非聚合物分子。合成测试化合物可以具有具有如酰胺，尿素，碳酸酯（即脲酯），酯，氨基，硫化物，二硫化物或碳-碳等链接的骨架结构，例如烷烃和烯烃，或任何组合。提供了适用于不同连接化学的亚基的示例。合成测试化合物还可以是分子支架，例如单环或双环糖，类固醇，糖，杂环结构，多芳香族结构或其他能够作为支架的结构的衍生物。提供了适用的分子支架的示例。本发明还涉及合成此类文库的方法以及使用此类文库从合成测试化合物文库中识别和表征感兴趣的分子的方法。
• Topologically segregated, encoded solid phase libraries comprising
  申请人：Selectide Corporation

  公开号：US06090912A1

  公开（公告）日：2000-07-18

  The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon--carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

  本发明涉及合成测试化合物库，其附着于分离相合成支持物上。特别地，本发明涉及附着于分离相合成支持物上的合成测试化合物库，该库还包含编码分子，用于编码合成测试化合物的结构。这些分子可以是聚合物或多个非聚合物分子。每个固相合成支持珠子包含单一类型的合成测试化合物。合成测试化合物可以具有骨架结构，其链接包括酰胺、脲、碳酸酯（即脲醇）、酯、氨基、硫化物、二硫化物或碳-碳，例如烷烃和烯烃，或者任何这些的组合。提供了适用于不同链接化学的亚基示例。合成测试化合物还可以是分子支架，例如单环或双环碳水化合物、甾体、糖、杂环结构、多芳香族结构或其他能够作为支架的结构的衍生物。提供了适用的分子支架示例。本发明还涉及合成这种库的方法以及使用这种库从合成测试化合物库中识别和表征感兴趣的分子的方法。