2-(1,3-dioxoisoindol-2-yl)-N-methyl-5-oxopentanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(1,3-dioxoisoindol-2-yl)-N-methyl-5-oxopentanamide
• 化学式: C₁₄H₁₄N₂O₄
• 分子量: 274.27
• InChiKey: NSVHJXXPWHTCDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] VARIANT CD58 DOMAINS AND USES THEREOF<br/>[FR] DOMAINES DE CD58 VARIANTS ET LEURS UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2020236797A1

  公开（公告）日：2020-11-26

  The present disclosure provides CD2 binding molecules that specifically bind to CD2, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD2 binding molecules, and pharmaceutical compositions comprising the CD2 binding molecules and the conjugates. The disclosure further provides methods of using the CD2 binding molecules to modulate CD2 signaling in order to treat a variety of immune (e.g., autoimmune), inflammatory and proliferative disorders. The disclosure yet further provides recombinant host cells engineered to express the CD2 binding molecules and methods of producing the CD2 binding molecules by culturing the host cells under conditions in which the CD2 binding molecules are expressed.