N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamides and their use as neurokinin 1 (NK1) and/or neurokinin 2 (NK2) receptor antagonists
申请人:Astrazeneca AB
公开号:US06403601B1
公开(公告)日:2002-06-11
Compounds of formula (I), wherein R2 is a 5,6,7,8-tetrahydronaphth-1-yl group which may be substituted (the remaining groups defined herein), and pharmaceutical compositions containing the compounds and methods of using the compounds in the treatment of a condition where antagonism of the NK1 and/or NK2 receptors is beneficial.
式(I)的化合物,其中R2是一个可以被取代的5,6,7,8-四氢萘基团(在此定义的其余基团),以及含有这些化合物的药物组合物和使用这些化合物治疗NK1和/或NK2受体拮抗有益的方法。