Spiroketals, isocoumarin, and indoleformic acid derivatives from saline soil derived fungus Penicillium raistrickii
作者:Li-Ying Ma、Wei-Zhong Liu、Li Shen、Yu-Ling Huang、Xian-Guo Rong、Yan-Yan Xu、Xue-Dong Gao
DOI:10.1016/j.tet.2012.01.054
日期:2012.3
Six new compounds, named peneciraistins A–F (1–6), were isolated from saline soil derived fungus Penicillium raistrickii. Among them, compounds 1 and 2 are rare benzannulate 6,6-spitoketals, and compounds 5 and 6 are the first naturally occurring 3-indoleformic acid derivatives. Their structures were elucidated by means of their detailed NMR and MS spectroscopic data. Their absolute configurations
六个新的化合物,命名为peneciraistins A-F(1 - 6),从盐土衍生真菌分离青霉raistrickii。其中,化合物1和2是稀有的苯甲酸6,6-spitoketals,化合物5和6是最早的天然存在的3-吲哚甲酸衍生物。通过详细的NMR和MS光谱数据阐明了它们的结构。通过与已知化合物的比较,通过改进的Mosher方法,CD激发手性方法或旋光性指定了它们的绝对构型。还报道了它们对A549和MCF-7细胞系的细胞毒性以及对DPPH(1,1-二苯基-2-吡啶并肼基)的自由基清除活性。