N-(6-methylbenzothiazol-2-yl)propanamide | 352687-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-(6-methylbenzothiazol-2-yl)propanamide
• 英文别名: N-(6-methyl-1,3-benzothiazol-2-yl)propanamide
• CAS: 352687-09-3
• 化学式: C₁₁H₁₂N₂OS
• mdl: MFCD01354638
• 分子量: 220.295
• InChiKey: FYVZICCAKDFHHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-6-甲基苯并噻唑 、 丙酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以52%的产率得到N-(6-methylbenzothiazol-2-yl)propanamide
  参考文献：
  名称：

  Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles

  摘要：

  In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modi. cations on these skeletons affected the antioxidant activity. Thiol and aminothiol compounds derived from thiadiazoles and benzothiazoles showed an interesting antioxidant property. The radioprotective activity has also been evaluated in mice. Some of these compounds could be good radioprotectors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.039

文献信息

• Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
  申请人：Getman P. Daniel

  公开号：US20070004646A1

  公开（公告）日：2007-01-04

  Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

  选择性杂环羰基氨基酸羟乙基氨磺酰胺化合物可作为逆转录病毒蛋白酶抑制剂，特别是作为HIV蛋白酶抑制剂。本发明涉及这种逆转录病毒蛋白酶抑制剂，更具体地涉及选择性新化合物、组合物和方法，用于抑制逆转录病毒蛋白酶，如人类免疫缺陷病毒（HIV）蛋白酶，预防逆转录病毒感染或逆转录病毒的传播，并治疗逆转录病毒感染。
• BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS
  申请人：Getman P. Daniel

  公开号：US20080118969A1

  公开（公告）日：2008-05-22

  Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

  选择性的双氨基酸羟乙基氨磺酰胺类化合物在逆转录病毒蛋白酶抑制剂中具有有效性，尤其是在HIV蛋白酶抑制剂中具有有效性。本发明涉及这种逆转录病毒蛋白酶抑制剂，更具体地涉及选择性的新化合物、组合物和方法，用于抑制逆转录病毒蛋白酶，如人类免疫缺陷病毒（HIV）蛋白酶，预防逆转录病毒感染或逆转录病毒的传播，以及治疗逆转录病毒感染。
• Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
  申请人：Getman P. Daniel

  公开号：US20070037754A1

  公开（公告）日：2007-02-15

  Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human inmmunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

  选择性的双氨基酸羟乙基氨磺酰胺化合物被证明是反转录病毒蛋白酶抑制剂，特别是HIV蛋白酶的抑制剂。本发明涉及这种反转录病毒蛋白酶抑制剂，更具体地涉及选定的新化合物、组合物和方法，用于抑制反转录病毒蛋白酶，例如人类免疫缺陷病毒（HIV）蛋白酶，预防反转录病毒感染或反转录病毒的传播，以及治疗反转录病毒感染。
• US7161033B2
  申请人：——

  公开号：US7161033B2

  公开（公告）日：2007-01-09
• US7339078B2
  申请人：——

  公开号：US7339078B2

  公开（公告）日：2008-03-04