C188-9 | 432001-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: C188-9
• 英文别名: N-(1',2-dihydroxy-1,2'-binaphthalen-4'-yl)-4-methoxybenzenesulfonamide；N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide
• CAS: 432001-19-9
• 化学式: C₂₇H₂₁NO₅S
• 分子量: 471.533
• InChiKey: QDCJDYWGYVPBDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  C188-9 在 sodium periodate 、 silica gel 作用下， 以 丙酮 为溶剂， 反应 116.0h， 以2.3 g的产率得到N-[3-(2-hydroxynaphthalen-1-yl)-4-oxonaphthalen-1-ylidene]-4-methoxybenzenesulfonamide
  参考文献：
  名称：

  WO2019204614A5

  摘要：

  公开号：

  WO2019204614A5
• 作为产物：
  描述：

  N-(4-hydroxynaphthalen-1-yl)-4-methoxybenzenesulfonamide 在 sodium periodate 、 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 生成 C188-9
  参考文献：
  名称：

  [EN] THERAPEUTIC COMPOUNDS, FORMULATIONS, AND USE THEREOF
  [FR] COMPOSÉS THÉRAPEUTIQUES, FORMULATIONS ET LEUR UTILISATION

  摘要：

  The present disclosure, in part, is directed to compositions comprising a compound of formula (I): wherein the compositions are substantially free of an impurity, processes of producing thereof, and uses thereof.

  公开号：

  WO2024020409A1

文献信息

• INHIBITORS OF MITOCHONDRIAL STAT3 AND USES THEREOF IN MODULATION OF MAST CELL EXOCYTOSIS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd

  公开号：US20160113900A1

  公开（公告）日：2016-04-28

  The invention provides composition of matter comprising at least one STAT3 inhibiting moiety or any vehicle, matrix, nano- or micro-particle comprising the same, associated with at least one mitochondrial targeting moiety. The invention further provides compositions comprising said mitochondrial-targeted STAT3 inhibitor, methods and uses thereof in inhibiting mast cell degranulation and in treating disorders induced by activation of MC.

  该发明提供了一种物质组合物，包括至少一种STAT3抑制基团或任何载体、基质、纳米或微粒，该组合物与至少一种线粒体靶向基团相关联。该发明还提供了包含所述线粒体靶向STAT3抑制剂的组合物，以及在抑制肥大细胞脱颗粒和治疗由MC激活引起的疾病中的方法和用途。
• [EN] STAT3 INHIBITORS<br/>[FR] INHIBITEURS DE STAT3
  申请人：TVARDI INC

  公开号：WO2019204614A1

  公开（公告）日：2019-10-24

  Compounds as STAT3 inhibitors are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing conditions such as cancer, chronic inflammation, and fibrosis using the same, are described.

  本文描述了作为STAT3抑制剂的化合物。还描述了包含该化合物的制药组合物，制造该化合物的方法，以及使用该化合物治疗或预防癌症、慢性炎症和纤维化等疾病的方法。
• COMPOUNDS FOR THE TREATMENT OF COVID-19
  申请人：Dompe' Farmaceutici S.P.A.

  公开号：EP3875078A1

  公开（公告）日：2021-09-08

  The present invention relates to compounds that are able to inhibt 3CL protease of COVID-19 virus, SARS-Cov-2

  本发明涉及能够抑制 COVID-19 病毒、SARS-Cov-2 病毒的 3CL 蛋白酶的化合物。
• Methods and compositions for treatment of fibrosis
  申请人：Baylor College of Medicine

  公开号：US10112933B2

  公开（公告）日：2018-10-30

  Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction of the risk of fibrosis. In at least particular cases, the small molecules are inhibitors of STAT3.

  本发明的实施方案包括治疗、预防和/或降低有需要的个体纤维化风险的方法。在某些实施方案中，采用特定的小分子来治疗、预防和/或降低纤维化的风险。至少在特定情况下，小分子是 STAT3 的抑制剂。
• Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
  申请人：Baylor College of Medicine

  公开号：US10676455B2

  公开（公告）日：2020-06-09

  Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.

  本发明的实施方案包括治疗、预防和/或降低有需要的个体发生选自肌肉萎缩、肌无力、恶病质及其组合的疾病的风险或严重程度的方法。在某些实施方案中，采用特定的小分子来治疗、预防和/或降低肌肉萎缩的风险。至少在特定情况下，小分子是 STAT3 的抑制剂。