N5,N5-二甲基-2,5-嘧啶二胺 | 73418-85-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N5,N5-二甲基-2,5-嘧啶二胺
• 英文名称: N⁵,N⁵-dimethylpyrimidine-2,5-diamine
• 英文别名: 2-Amino-5-dimethylaminopyrimidin；N5,N5-Dimethylpyrimidine-2,5-diamine；5-N,5-N-dimethylpyrimidine-2,5-diamine
• CAS: 73418-85-6
• 化学式: C₆H₁₀N₄
• mdl: MFCD18812654
• 分子量: 138.172
• InChiKey: JUSOFUJWEWGZFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-5-碘嘧啶, 、 二甲胺 在 copper(l) iodide 、 (E)-6,7-二氢喹啉-8(5H)-酮肟 、 potassium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 以78%的产率得到N5,N5-二甲基-2,5-嘧啶二胺
  参考文献：
  名称：

  净水中常温铜催化的二甲胺和甲胺的芳基化

  摘要：

  已开发出纯净水中第一个室温下铜催化的二甲胺和甲胺的芳基化反应。使用CuI和6,7-二氢喹啉-8（5  H）-一种肟的组合催化剂，二甲胺与各种芳基卤化物芳基化，得到相应的产物，收率良好至极佳。此外，该催化使得能够将甲胺选择性芳基化以提供高收率的单芳基甲胺作为唯一产物。

  DOI：

  10.1002/adsc.201400785

文献信息

• NOVEL PYRIDONE CARBOXYLIC ACID DERIVATIVE OR SALT THEREOF
  申请人：WAKUNAGA PHARMACEUTICAL CO., LTD.

  公开号：US20200062752A1

  公开（公告）日：2020-02-27

  It is intended to provide a novel compound having high antitumor activity and low toxicity to normal cells. The present invention provides a pyridone carboxylic acid derivative represented by the following formula (1) or a salt thereof wherein R 1 represents a hydrogen atom, a halogen atom or the like; R 2 represents a hydrogen atom, a halogen atom or the like; R 3 to R 6 each represent a hydrogen atom or the like; R 7 represents a hydrogen atom or the like; R 8 represents a hydrogen atom, a halogen atom, the following formula (a) (wherein R a1 and R a2 each represent a hydrogen atom, a hydroxy group, an optionally substituted lower alkyl group or the like) or the like, or R 7 and R 8 together represent —N—OR 10 (wherein R 10 represents a hydrogen atom, an optionally substituted lower alkyl group, or an aralkyl group), or R 7 and R 8 form an optionally substituted 4- to 6-membered saturated hetero ring together with the adjacent carbon atom, or the like; R 9 represents a hydrogen atom or the like; X represents a nitrogen atom or the like; and Y represents a nitrogen atom or the like.

  本发明旨在提供一种具有高抗肿瘤活性和低毒性对正常细胞的新型化合物。本发明提供一种由以下式(1)表示的吡啶酮羧酸衍生物或其盐，其中R1代表氢原子、卤素原子或类似物；R2代表氢原子、卤素原子或类似物；R3至R6各自代表氢原子或类似物；R7代表氢原子或类似物；R8代表氢原子、卤素原子、以下式(a)（其中Ra1和Ra2各自代表氢原子、羟基、可选择取代的低烷基基团或类似物）或类似物，或者R7和R8一起代表—N—OR10（其中R10代表氢原子、可选择取代的低烷基基团或芳基烷基基团），或者R7和R8与相邻碳原子一起形成可选择取代的4-至6元饱和杂环，或类似物；R9代表氢原子或类似物；X代表氮原子或类似物；Y代表氮原子或类似物。
• USE OF PI3K INHIBITORS FOR THE TREATMENT OF OBESITY, STEATOSIS AND AGEING
  申请人：Fundación Centro Nacional de Investigaciones Oncológicas Carlos III

  公开号：EP2629771B1

  公开（公告）日：2018-08-08
• 7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR INFALMMATORY DISEASES OR CANCER
  申请人：CELON PHARMA S.A.

  公开号：US20180111939A1

  公开（公告）日：2018-04-26

  A compound of the general formula (I) wherein Y represents —CH 2 — or >C=0; R 1 is selected from the group consisting of A1, A2 and A3; R 2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R 3 is selected from the group consisting of H, halogen, and C1-C4 alkyl; R 4 is selected from the group consisting of C1-C4 alkyl, C3-C4-cycloalkyl, C1-C4 alkyl substituted with C1-C4 alkoxy, and CHF 2 , and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.