(2S,3S,5R)-4-azido-6,8-dioxabicyclo[3.2.1]octane-2,3-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: (2S,3S,5R)-4-azido-6,8-dioxabicyclo[3.2.1]octane-2,3-diol
• 化学式: C6H9N3O4
• 分子量: 187.15
• InChiKey: HUGTZKVAMGZNKH-RKFISERESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  73.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ANTICOAGULANT COMPOUNDS
  申请人：Petitou Maurice

  公开号：US20100081708A1

  公开（公告）日：2010-04-01

  The present invention is concerned with anticoagulants (i.e. substances that stop blood from clotting). More specifically, the present invention is concerned with orally available antithrombic oligosaccharides.

  本发明涉及抗凝剂（即阻止血液凝结的物质）。更具体地说，本发明涉及口服可用的抗血栓寡糖。
• NOVEL ANTI-INFLAMMATORY PRO-DRUGS
  申请人：Aerts Johannes Maria Franciscus Gerardus

  公开号：US20100323976A1

  公开（公告）日：2010-12-23

  The present invention relates to compounds according to formula (I): wherein R 2 is absent or a linking moiety and R 3 is selected from the group consisting of anti- inflammatory agents and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising compounds of formula (I) and the use of these pharmaceutical compositions for the treatment or prophylaxis of chronic inflammatory diseases, in particular those that are caused by chronically activated macrophages. The chronic inflammatory disease is in particular atherosclerosis, (rheumatoid) arthritis, an (auto) immune disease or sarcoidosis.

  本发明涉及式(I)的化合物，其中R2不存在或为连接基，R3选自抗炎剂及其药学上可接受的盐，包括式(I)的化合物的药物组合物以及这些药物组合物用于治疗或预防慢性炎症性疾病，特别是那些由长期活化的巨噬细胞引起的疾病。慢性炎症性疾病特别是动脉粥样硬化、(类风湿)关节炎、(自身)免疫性疾病或结节病。