bis(4,4,4-trifluorobutyl)amine | 84138-09-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(4,4,4-trifluorobutyl)amine
• 英文别名: 4,4,4-trifluoro-N-(4,4,4-trifluorobutyl)butan-1-amine
• CAS: 84138-09-0
• 化学式: C₈H₁₃F₆N
• 分子量: 237.188
• InChiKey: ZKUUQPPGRWYGRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 三乙胺 、 4,4,4-三氟丁醛 生成 bis(4,4,4-trifluorobutyl)amine
  参考文献：
  名称：

  SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS

  摘要：

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：W、Q和G的定义如下。还公开了使用这些化合物作为Bcl-2家族抗凋亡蛋白的抑制剂用于治疗癌症的方法；以及包含这些化合物的药物组合物。

  公开号：

  US20140135318A1

文献信息

• [EN] SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS<br/>[FR] SULFONAMIDES SUBSTITUÉS UTILES COMME INHIBITEURS DE BCL ANTI-APOPTOTIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012162365A1

  公开（公告）日：2012-11-29

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  揭示了式（I）的化合物或其药学上可接受的盐，其中：W、Q和G在此处被定义。还揭示了将这些化合物用作Bcl-2家族抗凋亡蛋白的抑制剂以治疗癌症的方法；以及包含这些化合物的药物组合物。
• Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same
  申请人：Etna-TEC, Ltd.

  公开号：US20180334417A1

  公开（公告）日：2018-11-22

  A method of making a functionalized fluorinated monomer for use in making oligomers and polymers that can be used to improve surface properties of polymer-derived systems, such as coatings. The method of making a functionalized fluorinated monomer includes reacting at least one fluorinated nucleophilic reactant, such as a fluorinated alcohol, with at least one compound containing at least one epoxide group. Other methods include reaction of a fluorinated alcohol with a cyclic carboxylic anhydride. In another embodiment, a method includes reacting a fluorinated mesylate, tosylate or triflate with an amine, alkoxide or phenoxide. In other embodiments, the method includes reacting a fluorinated alcohol with an alkyl halide, or reacting a fluorinated alkyl halide with an amine. The functionalized fluorinated monomers may be used as intermediates and reacted to modify the functional groups thereon. Further, the functionalized fluorinated monomers may be reacted to form polymers or oligomers, or with polymers or oligomers having functional groups to modify the polymer or oligomer through the functional group thereon,

  一种制备用于制备寡聚物和聚合物的官能化氟化单体的方法，可用于改善聚合物衍生系统（如涂层）的表面性能。制备官能化氟化单体的方法包括将至少一种氟化亲核试剂（如氟化醇）与至少一种含有至少一个环氧基团的化合物反应。其他方法包括将氟化醇与环状羧酸酐反应。在另一实施例中，一种方法包括将氟化甲磺酸酯、对甲苯磺酸酯或三氟甲烷磺酸酯与胺、烷氧基或苯氧基反应。在其他实施例中，该方法包括将氟化醇与烷基卤化物反应，或将氟化烷基卤化物与胺反应。这些官能化氟化单体可用作中间体，并可反应以修改其上的官能基团。此外，这些官能化氟化单体可用于与聚合物或寡聚物反应，或与具有官能基团的聚合物或寡聚物反应，通过其上的官能基团修改聚合物或寡聚物。
• SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
  申请人：Borzilleri Robert M.

  公开号：US20140135318A1

  公开（公告）日：2014-05-15

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：W、Q和G的定义如下。还公开了使用这些化合物作为Bcl-2家族抗凋亡蛋白的抑制剂用于治疗癌症的方法；以及包含这些化合物的药物组合物。
• PRODUCTION METHOD FOR LITHIUM SULFAMATE, AND NOVEL LITHIUM SULFAMATE
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：EP3778565A1

  公开（公告）日：2021-02-17

  Provided is a method for producing a lithium sulfamate. The method for producing a lithium sulfamate includes (1) reacting a compound (1) represented by the following formula (1): wherein X is fluorine, chlorine, bromine, or iodine, with a compound (2) represented by the following formula (2) : wherein R1 and R2 are each individually a substituent that is: -H; a group represented by the formula: -Op-(SiR32O)n-SiR43 wherein R3 and R4 are each individually an alkyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom, an alkenyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom, an alkynyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom, or an aryl group in which at least one hydrogen atom is optionally replaced with a fluorine atom; n is an integer of 0 or greater; and p is 0 or 1; a C1-C7 alkyl group; a C2-C7 alkenyl group; a C2-C7 alkynyl group; a C6-C15 aryl group; -SO2X1 wherein X1 is -H, -F, or an alkyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom; -SO3X2 wherein X2 is -H, -F, or an alkyl group in which at least one hydrogen atom is optionally replaced with a fluorine atom; or a C2-C7 hydrocarbon group that forms a cyclic structure by bonding of R1 and R2, in which the cyclic structure optionally contains a multiple bond, the substituent optionally containing at least one bi- to hexavalent heteroatom in the structure and being a substituent in which at least one hydrogen atom is optionally replaced with a fluorine atom or a CO-C7 functional group, to obtain a compound (3) represented by the following formula (3): wherein R1 and R2 are defined as above.

  提供了一种生产氨基磺酸锂的方法。生产氨基磺酸锂的方法包括：（1）使下式（1）代表的化合物（1）反应： 其中 X 是氟、氯、溴或碘，与由下式（2）代表的化合物（2）反应： 其中 R1 和 R2 各自是一个取代基，该取代基是 -H; 由下式代表的基团-Op-(SiR32O)n-SiR43，其中 R3 和 R4 分别是至少一个氢原子可选地被氟原子取代的烷基、至少一个氢原子可选地被氟原子取代的烯基、至少一个氢原子可选地被氟原子取代的炔基或至少一个氢原子可选地被氟原子取代的芳基；n 是 0 或更大的整数；p 是 0 或 1； C1-C7 烷基 C2-C7 烯基 C2-C7炔基 C6-C15 芳基； -SO2X1，其中 X1 为-H、-F 或烷基，其中至少一个氢原子可选择被氟原子取代； -SO3X2，其中 X2 是-H、-F 或至少一个氢原子可选择被氟原子取代的烷基；或 通过 R1 和 R2 键合形成环状结构的 C2-C7 碳氢基团，其中环状结构可选择包含一个多键、 该取代基在结构中可选择含有至少一个双价至六价杂原子，并且是至少一个氢原子可选择被氟原子或 CO-C7 官能基取代的取代基，从而得到下式（3）所代表的化合物（3）： 其中 R1 和 R2 的定义同上。
• ELECTROLYTE SOLUTION, ELECTROCHEMICAL DEVICE, LITHIUM ION SECONDARY BATTERY, MODULE AND COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：EP3761435A1

  公开（公告）日：2021-01-06

  The disclosure provides an electrolyte solution that gives an electrochemical device having low resistance. The electrolyte solution contains a compound represented by the following formula (1). In the formula, R101 and R102 are each individually a substituent such as a C1-C7 alkyl group, the substituent optionally contains at least one divalent to hexavalent hetero atom in a structure or optionally has a structure obtained by replacing at least one hydrogen atom by a fluorine atom or a C0-C7 functional group, and at least one selected from the group consisting of R101 and R102, when both being an alkyl group, contains at least one divalent to hexavalent hetero atom in the structure or has a structure obtained by replacing at least one hydrogen atom by a fluorine atom or a C0-C7 functional group.

  本公开提供了一种电解质溶液，它能使电化学装置具有低电阻。该电解质溶液含有下式（1）所代表的化合物。式中，R101 和 R102 分别是取代基，如 C1-C7 烷基，取代基在结构中任选含有至少一个二价至六价杂原子，或任选具有通过用氟原子或 C0-C7 官能团取代至少一个氢原子而得到的结构、且至少有一个选自 R101 和 R102（当两者均为烷基时）组成的组，在结构上含有至少一个二价至六价杂原子，或具有通过用氟原子或 C0-C7 官能团取代至少一个氢原子而获得的结构。