O,O-二异丙基(3-氯丙基)膦酸酯 | 63602-20-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: O,O-二异丙基(3-氯丙基)膦酸酯
• 英文名称: O,O-diisopropyl (3-chloropropyl)phosphonate
• 英文别名: diisopropyl (3-chloropropyl)phosphonate；diisopropyl 3-chloropropylphosphonate；(3-chloro-propyl)-phosphonic acid diisopropyl ester；(3-Chlor-propyl)-phosphonsaeure-diisopropylester；1-chloro-3-di(propan-2-yloxy)phosphorylpropane
• CAS: 63602-20-0
• 化学式: C₉H₂₀ClO₃P
• 分子量: 242.683
• InChiKey: ZSOFQBXBNLFLSK-UHFFFAOYSA-N

物化性质

• 熔点：
  105-106 °C
• 沸点：
  106 °C(Press: 1.8 Torr)
• 密度：
  1.0707 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  O,O-二异丙基(3-氯丙基)膦酸酯 在 五氯化磷 作用下， 生成 dichloride of 3-chloropropylphosphonic acid
  参考文献：
  名称：

  A Study of the Reaction of Hydrocarbons with Phosphorus Trichloride and Oxygen¹

  摘要：

  DOI：

  10.1021/ja01604a025
• 作为产物：
  描述：

  三异丙基亚磷酸酯 、 1-氯-3-碘丙烷 生成 O,O-二异丙基(3-氯丙基)膦酸酯
  参考文献：
  名称：

  A Study of the Reaction of Hydrocarbons with Phosphorus Trichloride and Oxygen¹

  摘要：

  DOI：

  10.1021/ja01604a025

文献信息

• Synthesis, acid-base properties, and interphase distribution of new aminoalkylphosphates and -phosphonates
  作者：R. A. Cherkasov、A. R. Garifzyanov、N. S. Krasnova、M. V. Kazanova、A. V. Tarasov

  DOI：10.1134/s1070363208110078

  日期：2008.11

  Using the Todd-Atherton reaction, we synthesized new omega-aminoalkylphosphates differing by location of phosphate amino group in the molecule. For these compounds and for alpha-, beta-, and gamma-amino-phosphonates of similar structure ionization constants of phosphate and phosphonate groups were determined which turned out to be similar. In all the cases the increase in basicity of amine centers was shown with the growing distance between them and the phosphorus-containing substituent. By the method of two-phase potentiometric titration the constants of partition between water and a series of organic solvents were measured. The data obtained are interpreted in the framework of additive Leo-Hansch model that allows estimation of the increments of phosphate and amidophosphate groups. These data can be applied to the study of biological activity and extraction properties of the compound of such class.
• Synthesis and acid-base properties of some new γ-aminophosphoryl compounds
  作者：R. A. Cherkasov、A. R. Garifzyanov、N. V. Davletshina、A. V. Tarasov、D. I. Kushnikovskii

  DOI：10.1134/s1070363212080208

  日期：2012.8
• ——
  作者：V. S. Reznik、V. D. Akamsin、I. V. Galyametdinova

  DOI：10.1023/a:1009545706314

  日期：——

  The reactions of 3-chloropropylphosphonates, 3-chloropropylthiophosphonates, or 3-chloropropylphosphinates with 2-aryloxyethylamines or N-phenylpiperazine afford the corresponding 3-(2-aryloxyethylamino)propylphosphonates and -phosphinates or 3-(4-phenylpiperazin-1-yl)propylphosphonates and -phosphinates. The compounds obtained exhibit alpha -adrenolytic and hypotensive activities, the latter being found to depend on the substituents at the P atom.
• Synthesis of novel mono-and bisaminophosphoryl compounds and their membrane transport properties for acidic substrates
  作者：R. A. Cherkasov、A. S. Talan、A. V. Tarasov、A. P. Garifzyanov

  DOI：10.1134/s1070363208070062

  日期：2008.7

  Some novel aminophosphoryl compounds were synthesized by the Kabachnik-Fields reaction. Their membrane transport properties for mono-and polyfunctional carboxylic acids with different number of functional groups were studied to establish that the transport rate of acidic substrates through liquid impregnated membranes increases in going from mono-to diphosphoryl carriers. Additional hydrophilic groups in the substrate molecule, too, affect transport efficiency.
• A Study of the Reaction of Hydrocarbons with Phosphorus Trichloride and Oxygen¹
  作者：A. Furman Isbell、F. T. Wadsworth

  DOI：10.1021/ja01604a025

  日期：1956.12