5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone | 503174-32-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone
• 英文别名: 5-Ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenylfuran-2-one
• CAS: 503174-32-1
• 化学式: C₁₉H₁₈O₃S
• 分子量: 326.416
• InChiKey: SLBHFYYSAYOADU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone 在 Oxone 、 对甲苯磺酸 作用下， 以 丙酮 、 苯 为溶剂， 生成 5-Eth-(Z)-ylidene-3-(4-methanesulfonyl-phenyl)-4-phenyl-5H-furan-2-one
  参考文献：
  名称：

  A simple and rapid entry to 5-alkyl (aryl)-5-hydroxy-3,4-diarylfuranones and 3a-hydroxy-1-aryl-2,3a,4,5-tetrahydronaphthofuranones via a tandem esterification and oxidative cyclization process

  摘要：

  A synthesis of 5-hydroxy-3,4-diarylfuranones and related derivatives is accomplished by the reaction of arylacetic acid with alpha-bromoketone in the presence of base and atmospheric oxygen. A variety of compounds were synthesized in good to excellent yield and many are of potential biological interest. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02144-5
• 作为产物：
  描述：

  5-Ethyl-3-(4-methylsulfanyl-phenyl)-4-phenyl-5H-furan-2-one 在 氧气 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 生成 5-ethyl-5-hydroxy-3-(4-methylsulfanylphenyl)-4-phenyl-2,5-dihydro-2-furanone
  参考文献：
  名称：

  Pal, Manojit; Veeramaneni, Venugopal Rao; Padakanti, Srinivas, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 3, p. 593 - 601

  摘要：

  DOI：

文献信息

• A simple and rapid entry to 5-alkyl (aryl)-5-hydroxy-3,4-diarylfuranones and 3a-hydroxy-1-aryl-2,3a,4,5-tetrahydronaphthofuranones via a tandem esterification and oxidative cyclization process
  作者：Srinivas Padakanti、Venugopal Rao Veeramaneni、Vijaya Raghavan Pattabiraman、Manojit Pal、Koteswar Rao Yeleswarapu

  DOI：10.1016/s0040-4039(02)02144-5

  日期：2002.11

  A synthesis of 5-hydroxy-3,4-diarylfuranones and related derivatives is accomplished by the reaction of arylacetic acid with alpha-bromoketone in the presence of base and atmospheric oxygen. A variety of compounds were synthesized in good to excellent yield and many are of potential biological interest. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Pal, Manojit; Veeramaneni, Venugopal Rao; Padakanti, Srinivas, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 3, p. 593 - 601
  作者：Pal, Manojit、Veeramaneni, Venugopal Rao、Padakanti, Srinivas、Nagabelli, Murali、Vanguri, Akhila、Mamnoor, Premkumar、Casturi, Seshagiri Rao、Misra, Parimal、Mullangi, Ramesh、Yeleswarapu, Koteswar Rao

  DOI：——

  日期：——