3-[(2-Amino-phenyl)-methyl-amino]-propan-1-ol | 912284-79-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[(2-Amino-phenyl)-methyl-amino]-propan-1-ol
• 英文别名: 3-(2-amino-N-methylanilino)propan-1-ol
• CAS: 912284-79-8
• 化学式: C₁₀H₁₆N₂O
• 分子量: 180.25
• InChiKey: ATDILWQBEARROW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[(2-Amino-phenyl)-methyl-amino]-propan-1-ol 在 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 168.0h， 以68%的产率得到1-甲基-2,3,4,5-四氢-1H-1,5-苯并二氮杂卓
  参考文献：
  名称：

  Preparation of substituted 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines from catalytic Cp∗Ir hydrogen transfer N-heterocyclization of anilino alcohols

  摘要：

  The [Cp*IrCl2](2)/K2CO3 catalyzed hydrogen transfer N-heterocyclization on a series of anilino alcohols has been investigated. The catalyst (20% loading) converts anilino alcohols to 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines in 30-84% isolated yield. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.07.033
• 作为产物：
  描述：

  3-(甲基-(2-硝基苯基)氨基)丙酸 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 作用下， 生成 3-[(2-Amino-phenyl)-methyl-amino]-propan-1-ol
  参考文献：
  名称：

  Preparation of substituted 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines from catalytic Cp∗Ir hydrogen transfer N-heterocyclization of anilino alcohols

  摘要：

  The [Cp*IrCl2](2)/K2CO3 catalyzed hydrogen transfer N-heterocyclization on a series of anilino alcohols has been investigated. The catalyst (20% loading) converts anilino alcohols to 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines in 30-84% isolated yield. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2006.07.033

文献信息

• [EN] PROTECTING GROUPS FOR BORONIC ACIDS<br/>[FR] GROUPES DE PROTECTION POUR ACIDES BORONIQUES
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2014153041A1

  公开（公告）日：2014-09-25

  Di- and trivalent protecting groups for organoboronic acids including phenyl boronic acids, benzoxaboroles and benzoxaborins, which are prepared from precursor compounds of formulas I, IA-C, II, IIA-B, II I, IIIA and IV. Also provided are protected organoboronic acids including protected phenylboronic acids, benzoxaboroles and benzoxaborins. Also provides are methods for conducting reactions employing protected organoboronic acids.
• Preparation of substituted 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines from catalytic Cp∗Ir hydrogen transfer N-heterocyclization of anilino alcohols
  作者：C. Todd Eary、Dane Clausen

  DOI：10.1016/j.tetlet.2006.07.033

  日期：2006.9

  The [Cp*IrCl2](2)/K2CO3 catalyzed hydrogen transfer N-heterocyclization on a series of anilino alcohols has been investigated. The catalyst (20% loading) converts anilino alcohols to 1,2,3,4-tetrahydroquinoxalines and 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepines in 30-84% isolated yield. (c) 2006 Published by Elsevier Ltd.