O-beta-二乙基氨基乙基羟胺 | 6006-10-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: O-beta-二乙基氨基乙基羟胺
• 英文名称: N-2(diethylamino)-ethoxyamine
• 英文别名: O-(2-N,N-diethylaminoethyl)hydroxylamine；Diethylaminoethoxyamin；O-(β-Diethylaminoethyl)-hydroxylamin；O-(2-Diethylaminoethyl)-oxiamin；O-(2-Diaethylamino-aethyl)-hydroxylamin；O-(2-diethylamino-ethyl)-hydroxylamine；2-(N,N-diethylamino)ethoxyamine；(2-Diaethylamino-aethoxy)-amin；Ethanamine, 2-(aminooxy)-N,N-diethyl-；O-[2-(diethylamino)ethyl]hydroxylamine
• CAS: 6006-10-6
• 化学式: C₆H₁₆N₂O
• 分子量: 132.206
• InChiKey: HDHCLUGKRJBUBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  ——	acetone-[O-(2-diethylamino-ethyl)-oxime ]	19083-57-9	C9H20N2O	172.271

反应信息

• 作为反应物：
  描述：

  7-氯-3-(3,4-二氯苯基)-3,4-二氢-10-羟基-1,9-(2H,10H)-吖啶二酮 、 O-beta-二乙基氨基乙基羟胺 以 乙醇 为溶剂， 反应 1.5h， 以87%的产率得到(1E)-7-chloro-3-(3,4-dichlorophenyl)-1-[2-(diethylamino)ethoxyimino]-10-hydroxy-3,4-dihydro-2H-acridin-9-one
  参考文献：
  名称：

  Antimalarial drugs. 64. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures

  摘要：

  To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-[(alkylamino)alkylene]imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates. Among structural modifications prepared, including N-10-alkyl and C2-substituted analogs, removal of the C-9 oxygen, and introduction of an imino side chain at C-9, the imines of the N-10-H acridinediones were the most active compounds obtained. The [3-(NN-dimethylamino)propyl]imino derivative of 7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

  DOI：

  10.1021/jm00097a001
• 作为产物：
  描述：

  N,N-二乙基氯乙胺 在 盐酸 、 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 O-beta-二乙基氨基乙基羟胺
  参考文献：
  名称：

  Schenone; Minardi, Farmaco, Edizione Scientifica, 1968, vol. 23, # 9, p. 881 - 894

  摘要：

  DOI：
• 作为试剂：
  描述：

  甲萘醌 在 O-beta-二乙基氨基乙基羟胺 作用下， 生成 2-methyl-[1,4]naphthoquinone-4-[O-(2-diethylamino-ethyl)-oxime ]
  参考文献：
  名称：

  45. 2-甲基萘水溶性衍生物的制备

  摘要：

  DOI：

  10.1039/jr9480000182

文献信息

• NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20200062729A1

  公开（公告）日：2020-02-27

  The invention relates to novel compounds of the formula (I) in which Z, Y, A 1 , A 2 , A 3 , A 4 , X, R 7 , R 8 and R 9 have the meanings mentioned above, and processes and intermediates for the preparation thereof, and their use for controlling animal pests, in particular insects.

  该发明涉及公式（I）中的新化合物，其中Z、Y、A1、A2、A3、A4、X、R7、R8和R9具有上述提及的含义，以及其制备的过程和中间体，以及它们用于控制动物害虫，特别是昆虫。
• Benzomorphan Analogs and the Use Thereof
  申请人：LOCKMAN Jeffrey

  公开号：US20140135351A1

  公开（公告）日：2014-05-15

  The present invention is directed to Benzomorphan Analog compounds of the Formula I″, Formula IA″, Formula IB″, Formula IC″, or Formula ID″ as shown below; and related Formula I′, Formula IA′, Formula IB′, Formula IC′, or Formula ID′; Formula I, Formula IA, Formula IB, Formula IC, or Formula ID; wherein R 1 , R 2a , R 2b , R 3 and R 4 are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

  本发明涉及以下所示的Formula I″、Formula IA″、Formula IB″、Formula IC″或Formula ID″的苯吗啡类似物化合物；以及相关的Formula I′、Formula IA′、Formula IB′、Formula IC′或Formula ID′；Formula I、Formula IA、Formula IB、Formula IC或Formula ID；其中R1、R2a、R2b、R3和R4如本文所定义。本发明的化合物可用于治疗疼痛、便秘以及受阿片类和ORL-1受体活性调节的其他疾病。
• Cyclic Urea Derivatives As Androgen Receptor Antagonists
  申请人：Bock Mark Gary

  公开号：US20140329858A1

  公开（公告）日：2014-11-06

  The present invention is directed to compounds of formula (I) wherein R 1 , R 2 , R 3 , and A are defined herein. The present invention also provides for pharmaceutical compositions comprising a compound of formula (I) as well as to the use of such compounds as androgen receptor antagonists for the treatment of diseases and conditions mediated by the androgen receptor, such as prostate cancer.

  本发明涉及式（I）中R1、R2、R3和A所定义的化合物。本发明还提供了包含式（I）化合物的药物组合物，以及将这些化合物用作雄激素受体拮抗剂治疗由雄激素受体介导的疾病和症状，如前列腺癌。
• Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest
  申请人：Behrens Carsten

  公开号：US20060198819A1

  公开（公告）日：2006-09-07

  This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.

  本发明涉及新型化合物，选择性化学共轭方法和将其用于诊断和/或治疗目的的用途。
• Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
  申请人：Anikin Alexey Vyacheslavovich

  公开号：US20080207635A1

  公开（公告）日：2008-08-28

  The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.

  本发明提供了能够调节酪氨酸激酶的化合物，包括这些化合物的组合物和使用它们的方法。