2-[Hydroxy-(2-hydroxy-3-octadecoxypropoxy)phosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[Hydroxy-(2-hydroxy-3-octadecoxypropoxy)phosphoryl]oxyethyl-trimethylazanium
• 化学式: C26H57NO6P+
• 分子量: 510.7
• InChiKey: XKBJVQHMEXMFDZ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  34
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• (PHOSPHO)LIPIDS FOR COMBATTING HEPATITIS B VIRUS INFECTION
  申请人：WAKE FOREST UNIVERSITY

  公开号：EP0702556A1

  公开（公告）日：1996-03-27
• NOVEL ALKYL PHOSPHOLIPID DERIVATIVES WITH REDUCED CYTOTOXICITY AND USES THEREOF
  申请人：PERRISSOUD Daniel

  公开号：US20070167408A1

  公开（公告）日：2007-07-19

  The present invention provides novel alkyl phospholipid derivatives with reduced cytotoxicity that are useful for treating various diseases and/or pathophysiological conditions in mammals, preferably humans, that are caused by microorganisms, in particular bacteria, fungi, protozoa and/or viruses. Such alkyl phospholipids can be employed as single drugs or in the course of combination therapies and can also be used for the treatment of tumors.
• US5770584A
  申请人：——

  公开号：US5770584A

  公开（公告）日：1998-06-23
• US6030960A
  申请人：——

  公开号：US6030960A

  公开（公告）日：2000-02-29
• [EN] (PHOSPHO)LIPIDS FOR COMBATTING HEPATITIS B VIRUS INFECTION<br/>[FR] (PHOSPHO)LIPIDES CONTRE L'INFECTION A VIRUS DE L'HEPATITE B
  申请人：——

  公开号：WO1994028908A2

  公开（公告）日：1994-12-22

  [EN] A method of treating hepatitis B virus is disclosed. The method comprises administering to a subject in need of such treatment a hepatitis B combatting amount of alkyl ether phospholipids and alkyl ether phospholipid derivatives.
  [FR] L'invention concerne un procédé de traitement du virus de l'hépatite B. Le procédé consiste à administrer à un sujet nécessitant ce traitement une dose de phospholipides d'alkyle éther et de dérivés de phospholipides d'alkyle éther efficace pour combattre le virus de l'hépatite B.