cresyl violet | 114567-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: cresyl violet
• 英文别名: nile blue A chloride；Nile blue chloride；Nile blue；nile blue A；NBA；N,N-Diethyl-5-iminobenzo[a]phenoxazin-9-amine;hydrochloride
• CAS: 114567-73-6
• 化学式: C₂₀H₂₀N₃O*Cl
• mdl: MFCD00011936
• 分子量: 353.851
• InChiKey: SHXOKQKTZJXHHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.33
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  50.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cresyl violet 、 对苯二甲酰氯 以2%的产率得到
  参考文献：
  名称：

  POLASEK, MIROSLAV;GORTON, LO;APPELQVIST, ROGER;MARKO-VARGA, GYORGY;JOHANS+, ANAL. CHIM. ACTA, 246,(1991) N, C. 283-292

  摘要：

  DOI：

文献信息

• Raf inhibitor compounds and methods of use thereof
  申请人：Miknis Greg

  公开号：US20070049603A1

  公开（公告）日：2007-03-01

  Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  公式I的化合物对抑制Raf激酶和治疗由此介导的疾病有用。公开了使用公式I的化合物及其立体异构体、几何异构体、互变异构体、溶剂合物和药学上可接受的盐，在哺乳动物细胞中进行体外、体内和体内诊断、预防或治疗此类疾病或相关病理条件的方法。
• RADIOSENSITIVITY OF FLUOROPHORES AND USE OF RADIOPROTECTIVE AGENTS FOR DUAL-MODALITY IMAGING
  申请人：Immunomedics, Inc.

  公开号：US20160199524A1

  公开（公告）日：2016-07-14

  The present application discloses compositions and methods of use of dual-labeled molecules comprising a fluorescent probe and a radionuclide. The labeled molecules are of use for detection, imaging and/or diagnosis of diseased tissues, such as tumors. In preferred embodiments, the dual-labeled molecules are of use in pre-operative and/or intraoperative imaging, for example to detect margins of malignant tissues to facilitate surgical resectioning. In more preferred embodiments, a radioprotective agent such as an oxygen radical scavenger is used to decrease radiolysis of the fluorescent signal. The labeled molecules bind to a disease-associated antigen, such as a tumor-associated antigen. Exemplary molecules include antibodies, antibody fragments, bispecific antibodies, targetable constructs and targeting peptides, such as bombesin analogues.

  本申请公开了一种包含荧光探针和放射性核素的双标记分子的组合物及其使用方法。这些标记分子可用于检测、成像和/或诊断疾病组织，如肿瘤。在优选实施例中，双标记分子可用于术前和/或术中成像，例如检测恶性组织的边缘以便于手术切除。在更优选的实施例中，使用放射保护剂，如氧自由基清除剂，以减少荧光信号的辐解。标记分子结合到与疾病相关的抗原，如肿瘤相关抗原。示例分子包括抗体、抗体片段、双特异性抗体、可靶向构建物和靶向肽，如炸弹素类似物。
• Imidazole derivatives as raf kinase inhibitors
  申请人：——

  公开号：US20040038964A1

  公开（公告）日：2004-02-26

  Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b).

  小说化合物（I）及其作为药物的用途，特别是作为Raf激酶抑制剂用于治疗神经创伤性疾病，癌症，慢性神经退行性疾病，疼痛，偏头痛和心脏肥大，其中Ar是a）或b）公式的一组。
• [EN] DENTAL COMPOSITIONS AND METHODS WITH ARYLSULFINATE SALTS<br/>[FR] COMPOSITIONS DENTAIRES ET PROCEDES FAISANT APPEL A DES SELS ARYLSULFINATES
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2005034884A1

  公开（公告）日：2005-04-21

  Polymerizable compositions and methods are provided that include an ethylenically unsaturated compound and an arylsulfinate salt. The polymerizable compositions are useful as hardenable dental compositions.

  提供了一种聚合物组合物和方法，其中包括一种乙烯基不饱和化合物和一种芳基磺酸盐。这种聚合物组合物可用作可硬化的牙科组合物。
• Nitrogen-containing heterocyclic compounds and their use as raf inhibitors
  申请人：——

  公开号：US20040209883A1

  公开（公告）日：2004-10-21

  Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.

  化合物及其作为药物的用途，特别是作为Raf激酶抑制剂治疗神经创伤性疾病、癌症、慢性神经退行性疾病、疼痛、偏头痛和心脏肥大。

表征谱图